CREB5

From Wikipedia, the free encyclopedia

CAMP responsive element binding protein 5

Identifiers

CREB5; CRE-BPA

External IDs

Gene ontology
Molecular Function:	• transcription factor activity • zinc ion binding • sequence-specific DNA binding • metal ion binding • protein dimerization activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001011666 (mRNA)
NP_001011666 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 7: 28.42 - 28.83 Mb

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Pubmed search

[1]

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CAMP responsive element binding protein 5, also known as CREB5, is a human gene.^[1]

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: CREB5 cAMP responsive element binding protein 5.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440-5. doi:10.1038/88107. PMID 11329013.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074.
Nomura N, Zu YL, Maekawa T, et al. (1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1.". J. Biol. Chem. 268 (6): 4259-66. PMID 8440710.
Zu YL, Maekawa T, Nomura N, et al. (1993). "Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA.". Oncogene 8 (10): 2749-58. PMID 8378084.