CRB3

From Wikipedia, the free encyclopedia


Crumbs homolog 3 (Drosophila)
Identifiers
Symbol(s) CRB3;
External IDs OMIM: 609737 MGI: 2670904 HomoloGene: 18371
Orthologs
Human Mouse
Entrez 92359 224912
Ensembl ENSG00000130545 ENSMUSG00000044279
Uniprot Q9BUF7 Q8QZT4
Refseq NM_139161 (mRNA)
NP_631900 (protein)		 NM_177638 (mRNA)
NP_808306 (protein)
Location Chr 19: 6.41 - 6.42 Mb Chr 17: 56.75 - 56.75 Mb
Pubmed search [1] [2]

Crumbs homolog 3 (Drosophila), also known as CRB3, is a human gene.[1]

This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]

[edit] References

  1. ^ a b Entrez Gene: CRB3 crumbs homolog 3 (Drosophila).

[edit] Further reading

  • Lemmers C, Médina E, Delgrossi MH, et al. (2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells.". J. Biol. Chem. 277 (28): 25408-15. doi:10.1074/jbc.M202196200. PMID 11964389. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Makarova O, Roh MH, Liu CJ, et al. (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).". Gene 302 (1-2): 21-9. PMID 12527193. 
  • Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells.". J. Cell. Sci. 116 (Pt 14): 2895-906. doi:10.1242/jcs.00500. PMID 12771187. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Lemmers C, Michel D, Lane-Guermonprez L, et al. (2004). "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells.". Mol. Biol. Cell 15 (3): 1324-33. doi:10.1091/mbc.E03-04-0235. PMID 14718572. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Fogg VC, Liu CJ, Margolis B (2005). "Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells.". J. Cell. Sci. 118 (Pt 13): 2859-69. doi:10.1242/jcs.02412. PMID 15976445. 
  • Fan S, Fogg V, Wang Q, et al. (2007). "A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions.". J. Cell Biol. 178 (3): 387-98. doi:10.1083/jcb.200609096. PMID 17646395. 
 This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.