CRADD

From Wikipedia, the free encyclopedia

CASP2 and RIPK1 domain containing adaptor with death domain

PDB rendering based on 2o71.

Available structures: 2o71, 2of5, 3crd

Identifiers

Symbol(s)

CRADD; MGC9163; RAIDD

External IDs

OMIM: 603454 MGI: 1336168 HomoloGene: 2821

Gene ontology
Molecular Function:	• protein binding • caspase activity
Cellular Component:	• intracellular
Biological Process:	• proteolysis • signal transduction • induction of apoptosis via death domain receptors • regulation of apoptosis

Orthologs

Human

Mouse

Refseq

NM_003805 (mRNA)
NP_003796 (protein)

NM_009950 (mRNA)
NP_034080 (protein)

Location

Chr 12: 92.6 - 92.77 Mb

Chr 10: 94.6 - 94.75 Mb

Pubmed search

[1]

[2]

CASP2 and RIPK1 domain containing adaptor with death domain, also known as CRADD, is a human gene.^[1]

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: CRADD CASP2 and RIPK1 domain containing adaptor with death domain.

[edit] Further reading

Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression.". Genomics 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Duan H, Dixit VM (1997). "RAIDD is a new 'death' adaptor molecule.". Nature 385 (6611): 86–9. doi:10.1038/385086a0. PMID 8985253.
Ahmad M, Srinivasula SM, Wang L, et al. (1997). "CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.". Cancer Res. 57 (4): 615–9. PMID 9044836.
Chou JJ, Matsuo H, Duan H, Wagner G (1998). "Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment.". Cell 94 (2): 171–80. PMID 9695946.
Horvat S, Medrano JF (1999). "A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region.". Genomics 54 (1): 159–64. doi:10.1006/geno.1998.5540. PMID 9806843.
Shearwin-Whyatt LM, Harvey NL, Kumar S (2000). "Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD.". Cell Death Differ. 7 (2): 155–65. doi:10.1038/sj.cdd.4400632. PMID 10713730.
Chaudhary PM, Eby MT, Jasmin A, et al. (2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs.". Oncogene 19 (39): 4451–60. doi:10.1038/sj.onc.1203812. PMID 11002417.
Droin N, Beauchemin M, Solary E, Bertrand R (2001). "Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade.". Cancer Res. 60 (24): 7039–47. PMID 11156409.
Guo Y, Srinivasula SM, Druilhe A, et al. (2002). "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.". J. Biol. Chem. 277 (16): 13430–7. doi:10.1074/jbc.M108029200. PMID 11832478.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tinel A, Tschopp J (2004). "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.". Science 304 (5672): 843–6. doi:10.1126/science.1095432. PMID 15073321.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Park HH, Wu H (2006). "Crystal structure of RAIDD death domain implicates potential mechanism of PIDDosome assembly.". J. Mol. Biol. 357 (2): 358–64. doi:10.1016/j.jmb.2005.12.082. PMID 16434054.
Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B (2006). "Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.". Oncogene 25 (41): 5683–92. doi:10.1038/sj.onc.1209569. PMID 16652156.
Park HH, Wu H (2007). "Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (Pt 3): 229–32. doi:10.1107/S1744309107007889. PMID 17329820.