CPVL

From Wikipedia, the free encyclopedia


Carboxypeptidase, vitellogenic-like
Identifiers
Symbol(s) CPVL; HVLP; MGC10029
External IDs OMIM: 609780 MGI: 1918537 HomoloGene: 80235
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 54504 71287
Ensembl ENSG00000106066 n/a
Uniprot Q9H3G5 n/a
Refseq NM_019029 (mRNA)
NP_061902 (protein)		 XM_906883 (mRNA)
XP_911976 (protein)
Location Chr 7: 29 - 29.15 Mb n/a
Pubmed search [1] [2]

Carboxypeptidase, vitellogenic-like, also known as CPVL, is a human gene.[1]

The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. At least two alternatively spliced transcripts which encode the same protein have been observed.[1]

[edit] References

  1. ^ a b Entrez Gene: CPVL carboxypeptidase, vitellogenic-like.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Striebich CC, Falta MT, Wang Y, et al. (1998). "Selective accumulation of related CD4+ T cell clones in the synovial fluid of patients with rheumatoid arthritis.". J. Immunol. 161 (8): 4428–36. PMID 9780222. 
  • Wang X, Stollar BD (1999). "Immunoglobulin VH gene expression in human aging.". Clin. Immunol. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689. 
  • Ignatovich O, Tomlinson IM, Popov AV, et al. (2000). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire.". J. Mol. Biol. 294 (2): 457–65. doi:10.1006/jmbi.1999.3243. PMID 10610771. 
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152. 
  • Mahoney JA, Ntolosi B, DaSilva RP, et al. (2001). "Cloning and characterization of CPVL, a novel serine carboxypeptidase, from human macrophages.". Genomics 72 (3): 243–51. doi:10.1006/geno.2000.6484. PMID 11401439. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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