CPSF6

From Wikipedia, the free encyclopedia

Cleavage and polyadenylation specific factor 6, 68kDa

Identifiers

CPSF6; CFIM; CFIM68; HPBRII-4; HPBRII-7

External IDs

OMIM: 604979 MGI: 1913948 HomoloGene: 5091

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • protein binding
Cellular Component:	• nucleus • mRNA cleavage factor complex • paraspeckles
Biological Process:	• mRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007007 (mRNA)
NP_008938 (protein)

XM_984539 (mRNA)
XP_989633 (protein)

Location

Chr 12: 67.92 - 67.95 Mb

Chr 10: 116.75 - 116.78 Mb

Pubmed search

[1]

[2]

Cleavage and polyadenylation specific factor 6, 68kDa, also known as CPSF6, is a human gene.^[1]

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitement of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.^[1]

[edit] References

^ ^a ^b Entrez Gene: CPSF6 cleavage and polyadenylation specific factor 6, 68kDa.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Rüegsegger U, Beyer K, Keller W (1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors.". J. Biol. Chem. 271 (11): 6107–13. PMID 8626397.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Rüegsegger U, Blank D, Keller W (1998). "Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits.". Mol. Cell 1 (2): 243–53. PMID 9659921.
de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMID 11060040.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Awasthi S, Alwine JC (2003). "Association of polyadenylation cleavage factor I with U1 snRNP.". RNA 9 (11): 1400–9. PMID 14561889.
Brown KM, Gilmartin GM (2004). "A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im.". Mol. Cell 12 (6): 1467–76. PMID 14690600.
Dettwiler S, Aringhieri C, Cardinale S, et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.". J. Biol. Chem. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Venkataraman K, Brown KM, Gilmartin GM (2005). "Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition.". Genes Dev. 19 (11): 1315–27. doi:10.1101/gad.1298605. PMID 15937220.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Millevoi S, Loulergue C, Dettwiler S, et al. (2006). "An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries.". EMBO J. 25 (20): 4854–64. doi:10.1038/sj.emboj.7601331. PMID 17024186.
Cardinale S, Cisterna B, Bonetti P, et al. (2007). "Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit.". Mol. Biol. Cell 18 (4): 1282–92. doi:10.1091/mbc.E06-09-0846. PMID 17267687.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.