CPSF1

From Wikipedia, the free encyclopedia

Cleavage and polyadenylation specific factor 1, 160kDa

Identifiers

CPSF1; CPSF160; HSU37012; P/cl.18

External IDs

OMIM: 606027 MGI: 2679722 HomoloGene: 40865

Gene ontology
Molecular Function:	• RNA binding • mRNA 3'-UTR binding • protein binding
Cellular Component:	• nucleus • mRNA cleavage and polyadenylation specificity factor complex
Biological Process:	• mRNA polyadenylation • mRNA cleavage

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013291 (mRNA)
NP_037423 (protein)

XM_001000171 (mRNA)
XP_001000171 (protein)

Location

Chr 8: 145.59 - 145.61 Mb

Chr 15: 76.42 - 76.43 Mb

Pubmed search

[1]

[2]

Cleavage and polyadenylation specific factor 1, 160kDa, also known as CPSF1, is a human gene.^[1]

[edit] References

^ Entrez Gene: CPSF1 cleavage and polyadenylation specific factor 1, 160kDa.

[edit] Further reading

Keller W, Bienroth S, Lang KM, Christofori G (1992). "Cleavage and polyadenylation factor CPF specifically interacts with the pre-mRNA 3' processing signal AAUAAA.". EMBO J. 10 (13): 4241-9. PMID 1756731.
Murthy KG, Manley JL (1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation.". Genes Dev. 9 (21): 2672-83. PMID 7590244.
Jenny A, Keller W (1995). "Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor.". Nucleic Acids Res. 23 (14): 2629-35. PMID 7651824.
Thuresson AC, Aström J, Aström A, et al. (1994). "Multiple forms of poly(A) polymerases in human cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 979-83. PMID 8302877.
Schul W, Groenhout B, Koberna K, et al. (1996). "The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA.". EMBO J. 15 (11): 2883-92. PMID 8654386.
McCracken S, Fong N, Yankulov K, et al. (1997). "The C-terminal domain of RNA polymerase II couples mRNA processing to transcription.". Nature 385 (6614): 357-61. doi:10.1038/385357a0. PMID 9002523.
Dantonel JC, Murthy KG, Manley JL, Tora L (1997). "Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA.". Nature 389 (6649): 399-402. doi:10.1038/38763. PMID 9311784.
Takagaki Y, Manley JL (2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component.". Mol. Cell. Biol. 20 (5): 1515-25. PMID 10669729.
de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.". EMBO J. 19 (21): 5895-904. doi:10.1093/emboj/19.21.5895. PMID 11060040.
Samiotaki M, Balatsos NA, Courtis N, Tsiapalis CM (2001). "Assignment of the 160-kDa subunit of cleavage and polyadenylation specificity factor (CPSF1) to human chromosome 8q24.23 by radiation hybrid mapping.". Cytogenet. Cell Genet. 90 (3-4): 234-5. PMID 11124521.
McCracken S, Lambermon M, Blencowe BJ (2002). "SRm160 splicing coactivator promotes transcript 3'-end cleavage.". Mol. Cell. Biol. 22 (1): 148-60. PMID 11739730.
Maeda Y, Ito M, Harashima N, et al. (2002). "Cleavage and polyadenylation specificity factor (CPSF)-derived peptides can induce HLA-A2-restricted and tumor-specific CTLs in the majority of gastrointestinal cancer patients.". Int. J. Cancer 99 (3): 409-17. doi:10.1002/ijc.10377. PMID 11992410.
Holland L, Gauthier L, Bell-Rogers P, Yankulov K (2002). "Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme.". Eur. J. Biochem. 269 (21): 5192-202. PMID 12392551.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Kaufmann I, Martin G, Friedlein A, et al. (2005). "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.". EMBO J. 23 (3): 616-26. doi:10.1038/sj.emboj.7600070. PMID 14749727.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.