CPNE8

From Wikipedia, the free encyclopedia


Copine VIII
Identifiers
Symbol(s) CPNE8; MGC129645; MGC129646
External IDs MGI: 1914121 HomoloGene: 12049
Orthologs
Human Mouse
Entrez 144402 66871
Ensembl ENSG00000139117 n/a
Uniprot Q86YQ8 n/a
Refseq NM_153634 (mRNA)
NP_705898 (protein)		 NM_001033851 (mRNA)
NP_001029023 (protein)
Location Chr 12: 37.33 - 37.59 Mb n/a
Pubmed search [1] [2]

Copine VIII, also known as CPNE8, is a human gene.[1]

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.[1]

[edit] References

  1. ^ a b Entrez Gene: CPNE8 copine VIII.

[edit] Further reading

  • Creutz CE, Tomsig JL, Snyder SL, et al. (1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans.". J. Biol. Chem. 273 (3): 1393–402. PMID 9430674. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Tomsig JL, Creutz CE (2001). "Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein.". Biochemistry 39 (51): 16163–75. PMID 11123945. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Maitra R, Grigoryev DN, Bera TK, et al. (2003). "Cloning, molecular characterization, and expression analysis of Copine 8.". Biochem. Biophys. Res. Commun. 303 (3): 842–7. PMID 12670487. 
  • Ramsey H, Zhang DE, Richkind K, et al. (2003). "Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation.". Leukemia 17 (8): 1665–6. doi:10.1038/sj.leu.2403048. PMID 12886257. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901. 
 This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it.