CPA5

From Wikipedia, the free encyclopedia

Carboxypeptidase A5

Identifiers

CPA5; FLJ35969

External IDs

OMIM: 609561 MGI: 1921899 HomoloGene: 62246

Gene ontology
Molecular Function:	• carboxypeptidase activity • carboxypeptidase A activity • metallopeptidase activity • zinc ion binding • metal ion binding
Biological Process:	• proteolysis

Orthologs

Human

Mouse

Refseq

NM_080385 (mRNA)
NP_525124 (protein)

NM_144537 (mRNA)
NP_653120 (protein)

Location

Chr 7: 129.77 - 129.8 Mb

Chr 6: 30.56 - 30.58 Mb

Pubmed search

[1]

[2]

Carboxypeptidase A5, also known as CPA5, is a human gene.^[1]

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CPA5 carboxypeptidase A5.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Bentley L, Nakabayashi K, Monk D, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome.". J. Med. Genet. 40 (4): 249-56. PMID 12676894.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bonora E, Bacchelli E, Levy ER, et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.". Mol. Psychiatry 7 (3): 289-301. doi:10.1038/sj.mp.4001004. PMID 11920156.
Wei S, Segura S, Vendrell J, et al. (2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family.". J. Biol. Chem. 277 (17): 14954-64. doi:10.1074/jbc.M112254200. PMID 11836249.
"A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium." (1998). Hum. Mol. Genet. 7 (3): 571-8. PMID 9546821.