CPA4 (gene)

From Wikipedia, the free encyclopedia

Carboxypeptidase A4

PDB rendering based on 2bo9.

Available structures: 2bo9, 2boa, 2pcu

Identifiers

Symbol(s)

CPA4; CPA3

External IDs

OMIM: 607635 MGI: 1919041 HomoloGene: 56753

Gene ontology
Molecular Function:	• carboxypeptidase activity • carboxypeptidase A activity • metallopeptidase activity • zinc ion binding • metal ion binding
Cellular Component:	• cellular_component
Biological Process:	• proteolysis • histone acetylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016352 (mRNA)
NP_057436 (protein)

NM_027926 (mRNA)
NP_082202 (protein)

Location

Chr 7: 129.72 - 129.75 Mb

Chr 6: 30.52 - 30.54 Mb

Pubmed search

[1]

[2]

Carboxypeptidase A4, also known as CPA4, is a human gene.^[1]

This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness.^[1]

[edit] References

^ ^a ^b Entrez Gene: CPA4 carboxypeptidase A4.

[edit] Further reading

Huang H, Reed CP, Zhang JS, et al. (1999). "Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells.". Cancer Res. 59 (12): 2981–8. PMID 10383164.
Hayashida S, Yamasaki K, Asada Y, et al. (2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32.". Genomics 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kayashima T, Yamasaki K, Yamada T, et al. (2003). "The novel imprinted carboxypeptidase A4 gene ( CPA4) in the 7q32 imprinting domain.". Hum. Genet. 112 (3): 220–6. doi:10.1007/s00439-002-0891-3. PMID 12552318.
Bentley L, Nakabayashi K, Monk D, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome.". J. Med. Genet. 40 (4): 249–56. PMID 12676894.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
García-Castellanos R, Bonet-Figueredo R, Pallarés I, et al. (2005). "Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin.". Cell. Mol. Life Sci. 62 (17): 1996–2014. doi:10.1007/s00018-005-5174-4. PMID 16091843.