CPA3

From Wikipedia, the free encyclopedia

Carboxypeptidase A3 (mast cell)

Identifiers

External IDs

OMIM: 114851 MGI: 88479 HomoloGene: 74412

Gene ontology
Molecular Function:	• carboxypeptidase activity • carboxypeptidase A activity • metallopeptidase activity • zinc ion binding • metal ion binding
Cellular Component:	• secretory granule
Biological Process:	• proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001870 (mRNA)
NP_001861 (protein)

NM_007753 (mRNA)
NP_031779 (protein)

Location

Chr 3: 150.07 - 150.1 Mb

Chr 3: 20.41 - 20.43 Mb

Pubmed search

[1]

[2]

Carboxypeptidase A3 (mast cell), also known as CPA3, is a human gene.^[1]

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A3 form, is obtained as a binary complex of a procarboxypeptidase A with a proproteinase E. Mast cell carboxypeptidase A is a secretory granule metalloexopeptidase that has a pH optimum in the neutral to basic range. It resembles pancreatic carboxypeptidase A in cleaving COOH-terminal aromatic and aliphatic amino acid residues.^[1]

[edit] References

^ ^a ^b Entrez Gene: CPA3 carboxypeptidase A3 (mast cell).

[edit] Further reading

Natsuaki M, Stewart CB, Vanderslice P, et al. (1992). "Human skin mast cell carboxypeptidase: functional characterization, cDNA cloning, and genealogy.". J. Invest. Dermatol. 99 (2): 138-45. PMID 1629626.
Reynolds DS, Gurley DS, Austen KF (1992). "Cloning and characterization of the novel gene for mast cell carboxypeptidase A.". J. Clin. Invest. 89 (1): 273-82. PMID 1729276.
Goldstein SM, Kaempfer CE, Proud D, et al. (1987). "Detection and partial characterization of a human mast cell carboxypeptidase.". J. Immunol. 139 (8): 2724-9. PMID 2443571.
Reynolds DS, Gurley DS, Stevens RL, et al. (1990). "Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases.". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9480-4. PMID 2594780.
Goldstein SM, Kaempfer CE, Kealey JT, Wintroub BU (1989). "Human mast cell carboxypeptidase. Purification and characterization.". J. Clin. Invest. 83 (5): 1630-6. PMID 2708524.
Pascual R, Burgos FJ, Salva M, et al. (1989). "Purification and properties of five different forms of human procarboxypeptidases.". Eur. J. Biochem. 179 (3): 609-16. PMID 2920728.
Dikov MM, Springman EB, Yeola S, Serafin WE (1994). "Processing of procarboxypeptidase A and other zymogens in murine mast cells.". J. Biol. Chem. 269 (41): 25897-904. PMID 7929294.
Huang H, Reed CP, Zhang JS, et al. (1999). "Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells.". Cancer Res. 59 (12): 2981-8. PMID 10383164.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chen ZQ, He SH (2004). "Cloning and expression of human colon mast cell carboxypeptidase.". World J. Gastroenterol. 10 (3): 342-7. PMID 14760754.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.