CPA1

From Wikipedia, the free encyclopedia

Carboxypeptidase A1 (pancreatic)

Identifiers

External IDs

OMIM: 114850 MGI: 88478 HomoloGene: 55609

Gene ontology
Molecular Function:	• carboxypeptidase activity • carboxypeptidase A activity • metallopeptidase activity • zinc ion binding • metal ion binding
Cellular Component:	• extracellular space
Biological Process:	• proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001868 (mRNA)
NP_001859 (protein)

NM_025350 (mRNA)
NP_079626 (protein)

Location

Chr 7: 129.81 - 129.82 Mb

Chr 6: 30.59 - 30.6 Mb

Pubmed search

[1]

[2]

Carboxypeptidase A1 (pancreatic), also known as CPA1, is a human gene.^[1]

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. Carboxypeptidase A1 is a monomeric pancreatic exopeptidase. It is involved in zymogen inhibition.^[1]

[edit] References

^ ^a ^b Entrez Gene: CPA1 carboxypeptidase A1 (pancreatic).

[edit] Further reading

Catasús L, Villegas V, Pascual R, et al. (1992). "cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1.". Biochem. J. 287 ( Pt 1): 299-303. PMID 1417781.
Stewart EA, Craik CS, Hake L, Bowcock AM (1990). "Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter.". Am. J. Hum. Genet. 46 (4): 795-800. PMID 1969228.
Moulard M, Michon T, Kerfelec B, Chapus C (1990). "Further studies on the human pancreatic binary complexes involving procarboxypeptidase A.". FEBS Lett. 261 (1): 179-83. PMID 2307232.
Pascual R, Burgos FJ, Salva M, et al. (1989). "Purification and properties of five different forms of human procarboxypeptidases.". Eur. J. Biochem. 179 (3): 609-16. PMID 2920728.
Honey NK, Sakaguchi AY, Lalley PA, et al. (1986). "Assignment of the gene for carboxypeptidase A to human chromosome 7q22----qter and to mouse chromosome 6.". Hum. Genet. 72 (1): 27-31. PMID 3455919.
Velculescu VE, Zhang L, Vogelstein B, Kinzler KW (1995). "Serial analysis of gene expression.". Science 270 (5235): 484-7. PMID 7570003.
Laethem RM, Blumenkopf TA, Cory M, et al. (1996). "Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.". Arch. Biochem. Biophys. 332 (1): 8-18. doi:10.1006/abbi.1996.0310. PMID 8806703.
Bonora E, Bacchelli E, Levy ER, et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.". Mol. Psychiatry 7 (3): 289-301. doi:10.1038/sj.mp.4001004. PMID 11920156.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.