COX7A2

From Wikipedia, the free encyclopedia

Cytochrome c oxidase subunit VIIa polypeptide 2 (liver)

Identifiers

COX7A2; COX7AL; COX7AL1; COXVIIa-L; MGC118950; MGC118951; MGC118952; MGC126875; MGC126877

External IDs

OMIM: 123996 MGI: 1316715 HomoloGene: 36082

Gene ontology
Molecular Function:	• cytochrome-c oxidase activity • electron carrier activity
Cellular Component:	• mitochondrion • mitochondrial respiratory chain • membrane
Biological Process:	• electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001865 (mRNA)
NP_001856 (protein)

NM_009945 (mRNA)
NP_034075 (protein)

Location

Chr 6: 76 - 76.02 Mb

Chr 9: 79.54 - 79.55 Mb

Pubmed search

[1]

[2]

Cytochrome c oxidase subunit VIIa polypeptide 2 (liver), also known as COX7A2, is a human gene.^[1]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa and the polypeptide 2 is present in both muscle and nonmuscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, present in all tissues. This gene may have several pseudogenes.^[1]

[edit] References

^ ^a ^b Entrez Gene: COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver).

[edit] Further reading

Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex.". Prog. Nucleic Acid Res. Mol. Biol. 61: 309-44. PMID 9752724.
Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO (1992). "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart.". Eur. J. Biochem. 203 (1-2): 193-9. PMID 1309697.
Arnaudo E, Hirano M, Seelan RS, et al. (1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase.". Gene 119 (2): 299-305. PMID 1327965.
Fabrizi GM, Rizzuto R, Nakase H, et al. (1989). "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase.". Nucleic Acids Res. 17 (17): 7107. PMID 2550906.
Taanman JW, Hall RE, Tang C, et al. (1993). "Tissue distribution of cytochrome c oxidase isoforms in mammals. Characterization with monoclonal and polyclonal antibodies.". Biochim. Biophys. Acta 1225 (1): 95-100. PMID 8241294.
Merante F, Duncan AM, Mitchell G, et al. (1997). "Chromosomal localization of the human liver form cytochrome c oxidase subunit VIIa gene.". Genome 40 (3): 318-24. PMID 9202412.
Merante F, Ling M, Duncan AM, et al. (1997). "Cloning, characterization, and chromosomal localization of human liver form cytochrome c oxidase subunit VIa related genes.". Genome 40 (3): 325-31. PMID 9202413.
Hüttemann M, Mühlenbein N, Schmidt TR, et al. (2000). "Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene.". Biochim. Biophys. Acta 1492 (1): 252-8. PMID 11004498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.