COX6C

From Wikipedia, the free encyclopedia

Cytochrome c oxidase subunit VIc

Identifiers

External IDs

OMIM: 124090 MGI: 104614 HomoloGene: 3220

Gene ontology
Molecular Function:	• cytochrome-c oxidase activity • oxidoreductase activity
Cellular Component:	• mitochondrion • membrane • integral to membrane
Biological Process:	• electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004374 (mRNA)
NP_004365 (protein)

NM_053071 (mRNA)
NP_444301 (protein)

Location

Chr 8: 100.96 - 100.98 Mb

Chr 15: 35.88 - 35.88 Mb

Pubmed search

[1]

[2]

Cytochrome c oxidase subunit VIc, also known as COX6C, is a human gene.^[1]

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse COX subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene COX6CP1 has been found on chromosomes 16p12.^[1]

[edit] References

^ ^a ^b Entrez Gene: COX6C cytochrome c oxidase subunit VIc.

[edit] Further reading

Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex.". Prog. Nucleic Acid Res. Mol. Biol. 61: 309-44. PMID 9752724.
Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.". Biol. Chem. 388 (5): 457-65. doi:10.1515/BC.2007.059. PMID 17516841.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hofmann S, Lichtner P, Schuffenhauer S, et al. (1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping.". Cytogenet. Cell Genet. 83 (3-4): 226-7. PMID 10072584.
Kish SJ, Mastrogiacomo F, Guttman M, et al. (1999). "Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?". J. Neurochem. 72 (2): 700-7. PMID 9930743.
Wang FL, Wang Y, Wong WK, et al. (1996). "Two differentially expressed genes in normal human prostate tissue and in carcinoma.". Cancer Res. 56 (16): 3634-7. PMID 8705997.
Otsuka M, Mizuno Y, Yoshida M, et al. (1989). "Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc.". Nucleic Acids Res. 16 (22): 10916. PMID 2849755.