COX6B1

From Wikipedia, the free encyclopedia

Cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous)

Identifiers

COX6B1; COX6B; COXG

External IDs

OMIM: 124089 MGI: 107460 HomoloGene: 39658

Gene ontology
Molecular Function:	• cytochrome-c oxidase activity • oxidoreductase activity
Cellular Component:	• mitochondrion • mitochondrial inner membrane
Biological Process:	• electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001863 (mRNA)
NP_001854 (protein)

NM_025628 (mRNA)
NP_079904 (protein)

Location

Chr 19: 40.83 - 40.84 Mb

Chr 7: 30.33 - 30.33 Mb

Pubmed search

[1]

[2]

Cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous), also known as COX6B1, is a human gene.^[1]

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.^[1]

[edit] References

^ ^a ^b Entrez Gene: COX6B1 cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous).

[edit] Further reading

Taanman JW, Schrage C, Bokma E, et al. (1991). "Nucleotide sequence of the last exon of the gene for human cytochrome c oxidase subunit VIb and its flanking regions.". Biochim. Biophys. Acta 1089 (2): 283-5. PMID 1647217.
Taanman JW, van der Veen AY, Schrage C, et al. (1991). "Assignment of the gene coding for human cytochrome c oxidase subunit VIb to chromosome 19, band q13.1, by fluorescence in situ hybridisation.". Hum. Genet. 87 (3): 325-7. PMID 1650756.
Carrero-Valenzuela RD, Quan F, Lightowlers R, et al. (1991). "Human cytochrome c oxidase subunit VIb: characterization and mapping of a multigene family.". Gene 102 (2): 229-36. PMID 1651883.
Taanman JW, Schrage C, Ponne NJ, et al. (1990). "Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues.". Gene 93 (2): 285-91. PMID 2172092.
Taanman JW, Schrage C, Ponne N, et al. (1989). "Nucleotide sequence of cDNA encoding subunit VIb of human cytochrome c oxidase.". Nucleic Acids Res. 17 (4): 1766. PMID 2537962.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243-50. PMID 7821789.
Schmidt TR, Goodman M, Grossman LI (2002). "Amino acid replacement is rapid in primates for the mature polypeptides of COX subunits, but not for their targeting presequences.". Gene 286 (1): 13-9. PMID 11943455.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.". Biol. Chem. 388 (5): 457-65. doi:10.1515/BC.2007.059. PMID 17516841.