COX4I2

From Wikipedia, the free encyclopedia

Cytochrome c oxidase subunit IV isoform 2 (lung)

Identifiers

COX4I2; COX4; COX4-2; COX4B; COX4L2; COXIV-2; dJ857M17.2

External IDs

OMIM: 607976 MGI: 2135755 HomoloGene: 13082

Gene ontology
Molecular Function:	• cytochrome-c oxidase activity • oxidoreductase activity
Cellular Component:	• mitochondrion • mitochondrial respiratory chain complex IV • membrane
Biological Process:	• electron transport • cellular respiration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_032609 (mRNA)
NP_115998 (protein)

NM_053091 (mRNA)
NP_444321 (protein)

Location

Chr 20: 29.69 - 29.7 Mb

Chr 2: 152.45 - 152.46 Mb

Pubmed search

[1]

[2]

Cytochrome c oxidase subunit IV isoform 2 (lung), also known as COX4I2, is a human gene.^[1]

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.^[1]

[edit] References

^ ^a ^b Entrez Gene: COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung).

[edit] Further reading

Lynch SR, Sherman D, Copeland RA (1992). "Cytochrome c binding affects the conformation of cytochrome a in cytochrome c oxidase.". J. Biol. Chem. 267 (1): 298–302. PMID 1309738.
Garber EA, Margoliash E (1990). "Interaction of cytochrome c with cytochrome c oxidase: an understanding of the high- to low-affinity transition.". Biochim. Biophys. Acta 1015 (2): 279–87. PMID 2153405.
Bolli R, Nałecz KA, Azzi A (1985). "The interconversion between monomeric and dimeric bovine heart cytochrome c oxidase.". Biochimie 67 (1): 119–28. PMID 2986725.
Michel B, Bosshard HR (1984). "Spectroscopic analysis of the interaction between cytochrome c and cytochrome c oxidase.". J. Biol. Chem. 259 (16): 10085–91. PMID 6088481.
Hare JF, Ching E, Attardi G (1980). "Isolation, subunit composition, and site of synthesis of human cytochrome c oxidase.". Biochemistry 19 (10): 2023–30. PMID 6246917.
Papadopoulou LC, Tsiftsoglou AS (1996). "Effects of hemin on apoptosis, suppression of cytochrome c oxidase gene expression, and bone-marrow toxicity induced by doxorubicin (adriamycin).". Biochem. Pharmacol. 52 (5): 713–22. PMID 8765469.
Wiedemann FR, Vielhaber S, Schröder R, et al. (2000). "Evaluation of methods for the determination of mitochondrial respiratory chain enzyme activities in human skeletal muscle samples.". Anal. Biochem. 279 (1): 55–60. doi:10.1006/abio.1999.4434. PMID 10683230.
Hüttemann M, Kadenbach B, Grossman LI (2001). "Mammalian subunit IV isoforms of cytochrome c oxidase.". Gene 267 (1): 111–23. PMID 11311561.
Sampson V, Alleyne T (2002). "Cytochrome c/cytochrome c oxidase interaction. Direct structural evidence for conformational changes during enzyme turnover.". Eur. J. Biochem. 268 (24): 6534–44. PMID 11737208.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Vizirianakis IS, Pappas IS, Tsiftsoglou AS (2002). "Differentiation-dependent repression of c-myc, B22, COX II and COX IV genes in murine erythroleukemia (MEL) cells.". Biochem. Pharmacol. 63 (5): 1009–17. PMID 11911854.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Fukuda R, Zhang H, Kim JW, et al. (2007). "HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.". Cell 129 (1): 111–22. doi:10.1016/j.cell.2007.01.047. PMID 17418790.