COX4I1

From Wikipedia, the free encyclopedia

Cytochrome c oxidase subunit IV isoform 1

Identifiers

COX4I1; COX4; COXIV; MGC72016

External IDs

OMIM: 123864 MGI: 88473 HomoloGene: 37537

Gene ontology
Molecular Function:	• cytochrome-c oxidase activity • oxidoreductase activity
Cellular Component:	• mitochondrion • mitochondrial inner membrane • membrane
Biological Process:	• electron transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001861 (mRNA)
NP_001852 (protein)

NM_009941 (mRNA)
NP_034071 (protein)

Location

Chr 16: 84.39 - 84.4 Mb

Chr 8: 123.55 - 123.56 Mb

Pubmed search

[1]

[2]

Cytochrome c oxidase subunit IV isoform 1, also known as COX4I1, is a human gene.^[1]

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.^[1]

[edit] References

^ ^a ^b Entrez Gene: COX4I1 cytochrome c oxidase subunit IV isoform 1.

[edit] Further reading

Lithgow T (2000). "Targeting of proteins to mitochondria.". FEBS Lett. 476 (1-2): 22–6. PMID 10878243.
Van Kuilenburg AB, Van Beeumen JJ, Demol H, et al. (1992). "Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform.". Biochim. Biophys. Acta 1119 (2): 218–24. PMID 1311608.
Lomax MI, Hewett-Emmett D, Yang TL, Grossman LI (1992). "Rapid evolution of the human gene for cytochrome c oxidase subunit IV.". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5266–70. PMID 1319058.
Lomax MI, Welch MD, Darras BT, et al. (1990). "Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV.". Gene 86 (2): 209–16. PMID 2157630.
Romero N, Marsac C, Fardeau M, et al. (1990). "Immunohistochemical demonstration of fibre type-specific isozymes of cytochrome c oxidase in human skeletal muscle.". Histochemistry 94 (2): 211–5. PMID 2162812.
Zeviani M, Nakagawa M, Herbert J, et al. (1987). "Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase.". Gene 55 (2-3): 205–17. PMID 2444497.
Bonne G, Seibel P, Possekel S, et al. (1993). "Expression of human cytochrome c oxidase subunits during fetal development.". Eur. J. Biochem. 217 (3): 1099–107. PMID 8223633.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Wu W, Goodman M, Lomax MI, Grossman LI (1997). "Molecular evolution of cytochrome c oxidase subunit IV: evidence for positive selection in simian primates.". J. Mol. Evol. 44 (5): 477–91. PMID 9115172.
Bachman NJ, Wu W, Schmidt TR, et al. (1999). "The 5' region of the COX4 gene contains a novel overlapping gene, NOC4.". Mamm. Genome 10 (5): 506–12. PMID 10337626.
Hüttemann M, Kadenbach B, Grossman LI (2001). "Mammalian subunit IV isoforms of cytochrome c oxidase.". Gene 267 (1): 111–23. PMID 11311561.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Williams SL, Valnot I, Rustin P, Taanman JW (2004). "Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1.". J. Biol. Chem. 279 (9): 7462–9. doi:10.1074/jbc.M309232200. PMID 14607829.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Fukuda R, Zhang H, Kim JW, et al. (2007). "HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.". Cell 129 (1): 111–22. doi:10.1016/j.cell.2007.01.047. PMID 17418790.