COX1

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It has been suggested that this article or section be merged with Main subunit of cytochrome c oxidase. (Discuss)

Cytochrome c oxidase subunit I

PDB rendering based on 1occ.

Available structures: 1occ, 1oco, 1ocr, 1ocz, 1v54, 1v55, 2dyr, 2dys, 2eij, 2eik, 2eil, 2eim, 2ein, 2occ

Identifiers

Symbol(s)

COX1; MTCO1

External IDs

MGI: 102504 HomoloGene: 5016

Gene ontology
Molecular Function:	• cytochrome-c oxidase activity • iron ion binding • copper ion binding • protein binding • oxidoreductase activity • metal ion binding
Cellular Component:	• mitochondrion • mitochondrial respiratory chain • membrane • integral to membrane
Biological Process:	• mitochondrial electron transport, cytochrome c to oxygen • transport

Orthologs

Human

Mouse

Refseq

n/a (mRNA)
NP_536845 (protein)

n/a (mRNA)
NP_904330 (protein)

Location

Chr MT: 0.01 - 0.01 Mb

Pubmed search

[1]

[2]

Cytochrome c oxidase subunit I, also known as COX1, is a human protein and gene.^[1] It belongs to cytochrome c oxidase subunit I protein family.

[edit] References

^ Entrez Gene: COX1 cytochrome c oxidase subunit I.

[edit] Further reading

Torroni A, Achilli A, Macaulay V, et al. (2006). "Harvesting the fruit of the human mtDNA tree.". Trends Genet. 22 (6): 339-45. doi:10.1016/j.tig.2006.04.001. PMID 16678300.
Bodenteich A, Mitchell LG, Polymeropoulos MH, Merril CR (1993). "Dinucleotide repeat in the human mitochondrial D-loop.". Hum. Mol. Genet. 1 (2): 140. PMID 1301157.
Brown MD, Yang CC, Trounce I, et al. (1992). "A mitochondrial DNA variant, identified in Leber hereditary optic neuropathy patients, which extends the amino acid sequence of cytochrome c oxidase subunit I.". Am. J. Hum. Genet. 51 (2): 378-85. PMID 1322638.
Lu X, Walker T, MacManus JP, Seligy VL (1992). "Differentiation of HT-29 human colonic adenocarcinoma cells correlates with increased expression of mitochondrial RNA: effects of trehalose on cell growth and maturation.". Cancer Res. 52 (13): 3718-25. PMID 1377597.
Marzuki S, Noer AS, Lertrit P, et al. (1992). "Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.". Hum. Genet. 88 (2): 139-45. PMID 1757091.
Moraes CT, Andreetta F, Bonilla E, et al. (1991). "Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region.". Mol. Cell. Biol. 11 (3): 1631-7. PMID 1996112.
Attardi G, Chomyn A, Doolittle RF, et al. (1987). "Seven unidentified reading frames of human mitochondrial DNA encode subunits of the respiratory chain NADH dehydrogenase.". Cold Spring Harb. Symp. Quant. Biol. 51 Pt 1: 103-14. PMID 3472707.
Chomyn A, Cleeter MW, Ragan CI, et al. (1986). "URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit.". Science 234 (4776): 614-8. doi:10.1126/science.3764430. PMID 3764430.
Chomyn A, Mariottini P, Cleeter MW, et al. (1985). "Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.". Nature 314 (6012): 592-7. doi:10.1038/314592a0. PMID 3921850.
Sanger F, Coulson AR, Barrell BG, et al. (1981). "Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.". J. Mol. Biol. 143 (2): 161-78. doi:10.1016/0022-2836(80)90196-5. PMID 6260957.
Montoya J, Ojala D, Attardi G (1981). "Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs.". Nature 290 (5806): 465-70. doi:10.1038/290465a0. PMID 7219535.
Horai S, Hayasaka K, Kondo R, et al. (1995). "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.". Proc. Natl. Acad. Sci. U.S.A. 92 (2): 532-6. doi:10.1073/pnas.92.2.532. PMID 7530363.
Gattermann N, Retzlaff S, Wang YL, et al. (1997). "Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia.". Blood 90 (12): 4961-72. PMID 9389715.
Bröker S, Meunier B, Rich P, et al. (1998). "MtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase.". Eur. J. Biochem. 258 (1): 132-8. doi:10.1046/j.1432-1327.1998.2580132.x. PMID 9851701.
Andrews RM, Kubacka I, Chinnery PF, et al. (1999). "Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.". Nat. Genet. 23 (2): 147. doi:10.1038/13779. PMID 10508508.
Karadimas CL, Greenstein P, Sue CM, et al. (2000). "Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA.". Neurology 55 (5): 644-9. PMID 10980727.
Ingman M, Kaessmann H, Pääbo S, Gyllensten U (2001). "Mitochondrial genome variation and the origin of modern humans.". Nature 408 (6813): 708-13. doi:10.1038/35047064. PMID 11130070.
Finnilä S, Lehtonen MS, Majamaa K (2001). "Phylogenetic network for European mtDNA.". Am. J. Hum. Genet. 68 (6): 1475-84. doi:10.1086/320591. PMID 11349229.
Maca-Meyer N, González AM, Larruga JM, et al. (2003). "Major genomic mitochondrial lineages delineate early human expansions.". BMC Genet. 2: 13. PMID 11553319.