COX17

From Wikipedia, the free encyclopedia

COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)

Identifiers

COX17; MGC104397; MGC117386

External IDs

OMIM: 604813 MGI: 1333806 HomoloGene: 38089

Gene ontology
Molecular Function:	• copper ion binding • copper chaperone activity • metal ion binding
Cellular Component:	• cytoplasm • mitochondrion • mitochondrial intermembrane space
Biological Process:	• generation of precursor metabolites and energy • protein folding • copper ion transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005694 (mRNA)
NP_005685 (protein)

NM_001017429 (mRNA)
NP_001017429 (protein)

Location

Chr 3: 120.87 - 120.88 Mb

Chr 16: 38.27 - 38.27 Mb

Pubmed search

[1]

[2]

COX17 cytochrome c oxidase assembly homolog (S. cerevisiae), also known as COX17, is a human gene.^[1]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.^[1]

[edit] References

^ ^a ^b Entrez Gene: COX17 COX17 cytochrome c oxidase assembly homolog (S. cerevisiae).

[edit] Further reading

Amaravadi R, Glerum DM, Tzagoloff A (1997). "Isolation of a cDNA encoding the human homolog of COX17, a yeast gene essential for mitochondrial copper recruitment.". Hum. Genet. 99 (3): 329-33. PMID 9050918.
Punter FA, Adams DL, Glerum DM (2000). "Characterization and localization of human COX17, a gene involved in mitochondrial copper transport.". Hum. Genet. 107 (1): 69-74. PMID 10982038.
Horvath R, Lochmüller H, Stucka R, et al. (2000). "Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency.". Biochem. Biophys. Res. Commun. 276 (2): 530-3. doi:10.1006/bbrc.2000.3495. PMID 11027508.
Kako K, Tsumori K, Ohmasa Y, et al. (2000). "The expression of Cox17p in rodent tissues and cells.". Eur. J. Biochem. 267 (22): 6699-707. PMID 11054125.
Heaton DN, George GN, Garrison G, Winge DR (2001). "The mitochondrial copper metallochaperone Cox17 exists as an oligomeric, polycopper complex.". Biochemistry 40 (3): 743-51. PMID 11170391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Suzuki C, Daigo Y, Kikuchi T, et al. (2004). "Identification of COX17 as a therapeutic target for non-small cell lung cancer.". Cancer Res. 63 (21): 7038-41. PMID 14612491.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kako K, Takehara A, Arai H, et al. (2005). "A selective requirement for copper-dependent activation of cytochrome c oxidase by Cox17p.". Biochem. Biophys. Res. Commun. 324 (4): 1379-85. doi:10.1016/j.bbrc.2004.09.211. PMID 15504366.
Arnesano F, Balatri E, Banci L, et al. (2005). "Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding.". Structure 13 (5): 713-22. doi:10.1016/j.str.2005.02.015. PMID 15893662.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Cobine PA, Pierrel F, Leary SC, et al. (2006). "The P174L mutation in human Sco1 severely compromises Cox17-dependent metallation but does not impair copper binding.". J. Biol. Chem. 281 (18): 12270-6. doi:10.1074/jbc.M600496200. PMID 16520371.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63-72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Voronova A, Kazantseva J, Tuuling M, et al. (2007). "Cox17, a copper chaperone for cytochrome c oxidase: expression, purification, and formation of mixed disulphide adducts with thiol reagents.". Protein Expr. Purif. 53 (1): 138-44. doi:10.1016/j.pep.2006.11.014. PMID 17208454.
Voronova A, Meyer-Klaucke W, Meyer T, et al. (2007). "Oxidative switches in functioning of mammalian copper chaperone Cox17.". Biochem. J. 408 (1): 139-48. doi:10.1042/BJ20070804. PMID 17672825.