COTL1

From Wikipedia, the free encyclopedia

Coactosin-like 1 (Dictyostelium)

PDB rendering based on 1t2l.

Available structures: 1t2l, 1t3x, 1t3y, 1tmw, 1udm, 1vfq, 1wm4, 1wnj

Identifiers

Symbol(s)

COTL1; CLP; FLJ43657; MGC19733

External IDs

OMIM: 606748 MGI: 1919292 HomoloGene: 10898

Gene ontology
Molecular Function:	• actin binding • enzyme binding
Cellular Component:	• cellular_component • intracellular • cytoskeleton
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021149 (mRNA)
NP_066972 (protein)

NM_028071 (mRNA)
NP_082347 (protein)

Location

Chr 16: 83.16 - 83.21 Mb

Chr 8: 122.7 - 122.73 Mb

Pubmed search

[1]

[2]

Coactosin-like 1 (Dictyostelium), also known as COTL1, is a human gene.^[1]

This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.^[1]

[edit] References

^ ^a ^b Entrez Gene: COTL1 coactosin-like 1 (Dictyostelium).

[edit] Further reading

Wu C, Friedlander P, Lamoureux C, et al. (1993). "cDNA clones contain autonomous replication activity.". Biochim. Biophys. Acta 1174 (3): 241–57. PMID 7690594.
Chen KS, Manian P, Koeuth T, et al. (1997). "Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome.". Nat. Genet. 17 (2): 154–63. doi:10.1038/ng1097-154. PMID 9326934.
Provost P, Samuelsson B, Rådmark O (1999). "Interaction of 5-lipoxygenase with cellular proteins.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1881–5. PMID 10051563.
Provost P, Doucet J, Hammarberg T, et al. (2001). "5-Lipoxygenase interacts with coactosin-like protein.". J. Biol. Chem. 276 (19): 16520–7. doi:10.1074/jbc.M011205200. PMID 11297527.
Provost P, Doucet J, Stock A, et al. (2001). "Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75.". Biochem. J. 359 (Pt 2): 255–63. PMID 11583571.
Nakatsura T, Senju S, Ito M, et al. (2002). "Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method.". Eur. J. Immunol. 32 (3): 826–36. PMID 11870627.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dai H, Wu J, Xu Y, et al. (2005). "1H, 13C and 15N resonance assignments and the secondary structures of human coactosin like protein (hCLP) D123N.". J. Biomol. NMR 29 (3): 455–6. doi:10.1023/B:JNMR.0000032550.18424.aa. PMID 15213466.
Liu L, Wang Y, Zhang P, et al. (2005). "Expression, purification and preliminary crystallographic studies of human coactosin-like protein.". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 9): 1651–3. doi:10.1107/S0907444904016701. PMID 15333945.
Li X, Liu X, Lou Z, et al. (2005). "Crystal structure of human coactosin-like protein at 1.9 A resolution.". Protein Sci. 13 (11): 2845–51. doi:10.1110/ps.04937304. PMID 15459340.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Li X, Liu X, Zhao Q, et al. (2005). "Crystallization and preliminary crystallographic studies of human coactosin-like protein (CLP).". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 12 Pt 2): 2387–8. doi:10.1107/S0907444904028112. PMID 15583396.
Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.". Proteomics 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034.
Rakonjac M, Fischer L, Provost P, et al. (2006). "Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.". Proc. Natl. Acad. Sci. U.S.A. 103 (35): 13150–5. doi:10.1073/pnas.0605150103. PMID 16924104.
Dai H, Huang W, Xu J, et al. (2006). "Binding model of human coactosin-like protein with filament actin revealed by mutagenesis.". Biochim. Biophys. Acta 1764 (11): 1688–700. doi:10.1016/j.bbapap.2006.06.017. PMID 17070122.