Talk:Cori cycle
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[edit] Merge
The cori cycle is similar to the alanine cycle in that the requirement of energy causes molecules in the muscle to be broken down and the resulting residues are then sent to the liver for restoration to pyruvate (and usually then to glucose). However the cori cycle is initiated by the anaerobic oxidation of pyruvate in response to exercise (carbohydrate metabolism) and the resulting high blood lactic acid concentrations, whereas the alanine cycle is initiated by the body degrading protein stores (protein metabolism) to the amino acids alanine and glutamine in order to maintain blood glucose levels when no glucose is available in the diet and the glycogen stores have been exhausted. The reasons behind each are different though organs and final products involved are similar. The methods can be compared but should not be merged as they ARE different pathways involving different intermediates.
Agreed, I don't think this is a candidate for a merger without further reasoning - unless that merged was into a more general article. Orchid Righteous 11:06, 24 August 2006 (UTC)
[edit] Lactic Acidosis and Muscle Fatigue
From the most recent literature reviews I have read, it appears that many exercise physiologist believe that once common belief that lactic acidosis causes muscle fatigue/pain/cramps is incorrect.
As found in "Skeletal Muscle Fatigue: Cellular Mechanisms," (D. G. Allen, et al, Physiol. Rev. 88: 287-332, 2008, http://physrev.physiology.org/cgi/content/full/88/1/287)
"The traditional explanation, accumulation of intracellular lactate and hydrogen ions causing impaired function of the contractile proteins, is probably of limited importance in mammals."
This issue is addressed in the wikipedia article on lactic acid. The claim that "the accumulation of lactic acid causes muscle pain and cramps; however, normally before this happens the lactic acid is moved out of the muscles into the liver" should probably be corrected in this article. Mahasanti (talk) 19:00, 3 June 2008 (UTC)
