Cortisone alpha-reductase

From Wikipedia, the free encyclopedia

In enzymology, a cortisone alpha-reductase (EC 1.3.1.4) is an enzyme that catalyzes the chemical reaction

4,5alpha-dihydrocortisone + NADP⁺ cortisone + NADPH + H⁺

Thus, the two substrates of this enzyme are 4,5alpha-dihydrocortisone and NADP⁺, whereas its 3 products are cortisone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4,5alpha-dihydrocortisone:NADP+ Delta4-oxidoreductase. Other names in common use include cortisone Delta4-5alpha-reductase, microsomal steroid reductase (5alpha), Delta4-3-ketosteroid reductase (5alpha), Delta4-3-oxosteroid-5alpha-reductase, NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase, and Delta4-5alpha-reductase.

[edit] References

• IUBMB entry for 1.3.1.4
• BRENDA references for 1.3.1.4 (Recommended.)
• PubMed references for 1.3.1.4
• PubMed Central references for 1.3.1.4
• Google Scholar references for 1.3.1.4
• McGuire JS, Hollis VW and Tomkins GM (1960). "Some characteristics of the microsomal steroid reductases (5alpha) of rat liver". J. Biol. Chem. 235: 3112–3117. 

[edit] External links

The CAS registry number for this enzyme class is 9029-09-8.

• IUBMB entry for 1.3.1.4

• KEGG entry for 1.3.1.4

• BRENDA entry for 1.3.1.4

• NiceZyme view of 1.3.1.4

• EC2PDB: PDB structures for 1.3.1.4

• PRIAM entry for 1.3.1.4

• PUMA2 entry for 1.3.1.4

• IntEnz: Integrated Enzyme entry for 1.3.1.4

• MetaCyc entry for 1.3.1.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047786: cortisone alpha-reductase

• AMIGO entry for GO code 0047786: cortisone alpha-reductase