Corticosteroid side-chain-isomerase

From Wikipedia, the free encyclopedia

In enzymology, a corticosteroid side-chain-isomerase (EC 5.3.1.21) is an enzyme that catalyzes the chemical reaction

11-deoxycorticosterone 20-hydroxy-3-oxopregn-4-en-21-al

Hence, this enzyme has one substrate, 11-deoxycorticosterone, and one product, 20-hydroxy-3-oxopregn-4-en-21-al.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is 11-deoxycorticosterone aldose-ketose-isomerase.

[edit] References

• IUBMB entry for 5.3.1.21
• BRENDA references for 5.3.1.21 (Recommended.)
• PubMed references for 5.3.1.21
• PubMed Central references for 5.3.1.21
• Google Scholar references for 5.3.1.21
• Martin KO, Oh SW, Lee HJ, Monder C (1977). "Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme". Biochemistry. 16: 3803–9. doi:10.1021/bi00636a013. PMID 901753. 
• Monder C, Martin KO, Bogumil J (1980). "Presence of epimerase activity in hamster liver corticosteroid side chain isomerase". J. Biol. Chem. 255: 7192–8. PMID 7391077. 

[edit] External links

The CAS registry number for this enzyme class is 75139-73-0.

• IUBMB entry for 5.3.1.21

• KEGG entry for 5.3.1.21

• BRENDA entry for 5.3.1.21

• NiceZyme view of 5.3.1.21

• EC2PDB: PDB structures for 5.3.1.21

• PRIAM entry for 5.3.1.21

• PUMA2 entry for 5.3.1.21

• IntEnz: Integrated Enzyme entry for 5.3.1.21

• MetaCyc entry for 5.3.1.21

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004110: corticosteroid side-chain-isomerase

• AMIGO entry for GO code 0004110: corticosteroid side-chain-isomerase