CORIN

From Wikipedia, the free encyclopedia

Corin, serine peptidase

Identifiers

CORIN; ATC2; CRN; Lrp4; MGC119742; TMPRSS10

External IDs

OMIM: 605236 MGI: 1349451 HomoloGene: 4804

Gene ontology
Molecular Function:	• serine-type endopeptidase activity • scavenger receptor activity • peptidase activity
Cellular Component:	• plasma membrane • integral to plasma membrane
Biological Process:	• proteolysis • lipid metabolic process • blood pressure regulation • anatomical structure morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006587 (mRNA)
NP_006578 (protein)

NM_016869 (mRNA)
NP_058565 (protein)

Location

Chr 4: 47.29 - 47.53 Mb

Chr 5: 72.58 - 72.78 Mb

Pubmed search

[1]

[2]

Corin, serine peptidase, also known as CORIN, is a human gene.^[1]

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.^[1]

[edit] References

^ ^a ^b Entrez Gene: CORIN corin, serine peptidase.

[edit] Further reading

Yan W, Sheng N, Seto M, et al. (1999). "Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart.". J. Biol. Chem. 274 (21): 14926–35. PMID 10329693.
Yan W, Wu F, Morser J, Wu Q (2000). "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8525–9. doi:10.1073/pnas.150149097. PMID 10880574.
Hooper JD, Scarman AL, Clarke BE, et al. (2001). "Localization of the mosaic transmembrane serine protease corin to heart myocytes.". Eur. J. Biochem. 267 (23): 6931–7. PMID 11082206.
Wu F, Yan W, Pan J, et al. (2002). "Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes.". J. Biol. Chem. 277 (19): 16900–5. doi:10.1074/jbc.M201503200. PMID 11884416.
Pan J, Hinzmann B, Yan W, et al. (2002). "Genomic structures of the human and murine corin genes and functional GATA elements in their promoters.". J. Biol. Chem. 277 (41): 38390–8. doi:10.1074/jbc.M205686200. PMID 12154094.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Knappe S, Wu F, Masikat MR, et al. (2004). "Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin.". J. Biol. Chem. 278 (52): 52363–70. doi:10.1074/jbc.M309991200. PMID 14559895.
Knappe S, Wu F, Madlansacay MR, Wu Q (2004). "Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide.". J. Biol. Chem. 279 (33): 34464–71. doi:10.1074/jbc.M405041200. PMID 15192093.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Dries DL, Victor RG, Rame JE, et al. (2006). "Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.". Circulation 112 (16): 2403–10. doi:10.1161/CIRCULATIONAHA.105.568881. PMID 16216958.
Rame JE, Drazner MH, Post W, et al. (2007). "Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload.". Hypertension 49 (4): 857–64. doi:10.1161/01.HYP.0000258566.95867.9e. PMID 17296875.
Liao X, Wang W, Chen S, Wu Q (2007). "Role of glycosylation in corin zymogen activation.". J. Biol. Chem. 282 (38): 27728–35. doi:10.1074/jbc.M703687200. PMID 17660514.