COQ7 (gene)

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Coenzyme Q7 homolog, ubiquinone (yeast)
Identifiers
Symbol(s) COQ7; CLK-1; CLK1; CAT5
External IDs OMIM: 601683 MGI: 107207 HomoloGene: 6953
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10229 12850
Ensembl ENSG00000167186 ENSMUSG00000030652
Uniprot Q99807 Q8K359
Refseq NM_016138 (mRNA)
NP_057222 (protein)		 NM_009940 (mRNA)
NP_034070 (protein)
Location Chr 16: 18.99 - 19 Mb Chr 7: 118.3 - 118.32 Mb
Pubmed search [1] [2]

Coenzyme Q7 homolog, ubiquinone (yeast), also known as COQ7, is a human gene.[1]

The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Transcript variants have been described for this gene, but their full-length sequences have not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: COQ7 coenzyme Q7 homolog, ubiquinone (yeast).

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Ewbank JJ, Barnes TM, Lakowski B, et al. (1997). "Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.". Science 275 (5302): 980-3. PMID 9020081. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Jonassen T, Proft M, Randez-Gil F, et al. (1998). "Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis.". J. Biol. Chem. 273 (6): 3351-7. PMID 9452453. 
  • Freije JM, Blay P, Pendás AM, et al. (1999). "Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins.". Genomics 58 (3): 270-80. doi:10.1006/geno.1999.5834. PMID 10373325. 
  • Asaumi S, Kuroyanagi H, Seki N, Shirasawa T (1999). "Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human.". Genomics 58 (3): 293-301. doi:10.1006/geno.1999.5838. PMID 10373327. 
  • Vajo Z, King LM, Jonassen T, et al. (2000). "Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging.". Mamm. Genome 10 (10): 1000-4. PMID 10501970. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Stenmark P, Grünler J, Mattsson J, et al. (2001). "A new member of the family of di-iron carboxylate proteins. Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis.". J. Biol. Chem. 276 (36): 33297-300. doi:10.1074/jbc.C100346200. PMID 11435415. 
  • Takahashi M, Asaumi S, Honda S, et al. (2001). "Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans.". Biochem. Biophys. Res. Commun. 286 (3): 534-40. doi:10.1006/bbrc.2001.5439. PMID 11511092. 
  • Rea S (2002). "CLK-1/Coq7p is a DMQ mono-oxygenase and a new member of the di-iron carboxylate protein family.". FEBS Lett. 509 (3): 389-94. PMID 11749961. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
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