Coproporphyrinogen dehydrogenase

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In enzymology, a coproporphyrinogen dehydrogenase (EC 1.3.99.22) is an enzyme that catalyzes the chemical reaction

coproporphyrinogen III + 2 S-adenosyl-L-methionine $\rightleftharpoons$ protoporphyrinogen IX + 2 CO₂ + 2 L-methionine + 2 5'-deoxyadenosine

Thus, the two substrates of this enzyme are coproporphyrinogen III and S-adenosyl-L-methionine, whereas its 4 products are protoporphyrinogen IX, CO₂, L-methionine, and 5'-deoxyadenosine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating). Other names in common use include oxygen-independent coproporphyrinogen-III oxidase, HemN, radical SAM enzyme, and coproporphyrinogen III oxidase. This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

IUBMB entry for 1.3.99.22
BRENDA references for 1.3.99.22 (Recommended.)
PubMed references for 1.3.99.22
PubMed Central references for 1.3.99.22
Google Scholar references for 1.3.99.22
Layer G, Verfurth K, Mahlitz E, Jahn D (2002). "Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli". J. Biol. Chem. 277: 34136–42. doi:10.1074/jbc.M205247200. PMID 12114526.
Layer G, Moser J, Heinz DW, Jahn D, Schubert WD (2003). "Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes". EMBO. J. 22: 6214–24. doi:10.1093/emboj/cdg598. PMID 14633981.