CopA-like RNA

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CopA-like RNA
Template:Abbreviation
Type: Gene; antisense;
2° structure: Predicted; PFOLD; Moxon SJ
Seed alignment: Bateman A
Avg length: 90.2 nucleotides
Avg identity: 84%

In several groups of bacterial plasmids, antisense RNAs regulate copy number through inhibition of replication initiator protein synthesis. These RNAs are characterised by a long hairpin structure interrupted by several unpaired nucleotides or bulged loops. In plasmid R1, the inhibitory complex between the antisense RNA (CopA) and its target mRNA (CopT) is characterised by a four-way junction structure and a side-by-side helical alignment.[1]

[edit] References

  1. ^ Nordgren, S; Slagter-Jager JG, Wagner GH (2001). "Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance". J Mol Biol 310: 1125–1134. doi:10.1006/jmbi.2001.4802. PMID 11502000. 
  • Gerhart, E; Wagner H, Nordstrom K (1986). "Structural analysis of an RNA molecule involved in replication control of plasmid R1". Nucleic Acids Res 14: 2523–2538. doi:10.1093/nar/14.6.2523. PMID 2421250. 
  • Light, J; Molin S (1983). "Post-transcriptional control of expression of the repA gene of plasmid R1 mediated by a small RNA molecule". EMBO J 2: 93–98. PMID 11894917. 

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