COPA (gene)
From Wikipedia, the free encyclopedia
Coatomer protein complex, subunit alpha
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Identifiers | ||||||||||||||
Symbol(s) | COPA; FLJ26320; HEP-COP | |||||||||||||
External IDs | OMIM: 601924 MGI: 1334462 HomoloGene: 3218 | |||||||||||||
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RNA expression pattern | ||||||||||||||
Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 1314 | 12847 | ||||||||||||
Ensembl | ENSG00000122218 | ENSMUSG00000026553 | ||||||||||||
Uniprot | P53621 | n/a | ||||||||||||
Refseq | NM_004371 (mRNA) NP_004362 (protein) |
NM_009938 (mRNA) NP_034068 (protein) |
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Location | Chr 1: 158.53 - 158.58 Mb | Chr 1: 173.92 - 173.96 Mb | ||||||||||||
Pubmed search | [1] | [2] |
Coatomer protein complex, subunit alpha, also known as COPA, is a human gene.[1]
In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.[1]
[edit] References
[edit] Further reading
- Feurle GE (1998). "Xenin--a review.". Peptides 19 (3): 609–15. PMID 9533652.
- Feurle GE, Hamscher G, Kusiek R, et al. (1992). "Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion.". J. Biol. Chem. 267 (31): 22305–9. PMID 1429581.
- Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol.". Nature 364 (6439): 732–4. doi: . PMID 8355790.
- Lowe M, Kreis TE (1996). "In vitro assembly and disassembly of coatomer.". J. Biol. Chem. 270 (52): 31364–71. PMID 8537409.
- Chow VT, Quek HH (1996). "HEP-COP, a novel human gene whose product is highly homologous to the alpha-subunit of the yeast coatomer protein complex.". Gene 169 (2): 223–7. PMID 8647451.
- Fiedler K, Veit M, Stamnes MA, Rothman JE (1996). "Bimodal interaction of coatomer with the p24 family of putative cargo receptors.". Science 273 (5280): 1396–9. PMID 8703076.
- Faulstich D, Auerbach S, Orci L, et al. (1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex.". J. Cell Biol. 135 (1): 53–61. PMID 8858162.
- Lowe M, Kreis TE (1997). "In vivo assembly of coatomer, the COP-I coat precursor.". J. Biol. Chem. 271 (48): 30725–30. PMID 8940050.
- Quek HH, Chow VT (1997). "Molecular and cellular studies of the human homolog of the 160-kD alpha-subunit of the coatomer protein complex.". DNA Cell Biol. 16 (3): 275–80. PMID 9115636.
- Quek HH, Chow VT (1997). "Genomic organization and mapping of the human HEP-COP gene (COPA) to 1q.". Cytogenet. Cell Genet. 76 (3-4): 139–43. PMID 9186507.
- Hansen K, Rönnstrand L, Rorsman C, et al. (1997). "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor.". Biochem. Biophys. Res. Commun. 235 (3): 455–60. doi: . PMID 9207175.
- Chow VT, Quek HH (1997). "Alpha coat protein COPA (HEP-COP): presence of an Alu repeat in cDNA and identity of the amino terminus to xenin.". Ann. Hum. Genet. 61 (Pt 4): 369–73. doi: . PMID 9365789.
- Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex.". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. PMID 9482852.
- Harter C, Wieland FT (1998). "A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer.". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11649–54. PMID 9751720.
- Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport.". J. Biol. Chem. 276 (29): 27480–7. doi: . PMID 11323436.
- Yang JS, Lee SY, Gao M, et al. (2002). "ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat.". J. Cell Biol. 159 (1): 69–78. doi: . PMID 12379802.
- Xu Y, Martin S, James DE, Hong W (2003). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.". Mol. Biol. Cell 13 (10): 3493–507. doi: . PMID 12388752.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: . PMID 12477932.
- Wong N, Chan A, Lee SW, et al. (2003). "Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression.". J. Hepatol. 38 (3): 298–306. PMID 12586295.