COP1

From Wikipedia, the free encyclopedia

Caspase-1 dominant-negative inhibitor pseudo-ICE

Identifiers

COP1; COP; PSEUDO-ICE

Gene ontology
Molecular Function:	• protein binding • caspase activity
Cellular Component:	• intracellular
Biological Process:	• proteolysis • regulation of apoptosis

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001017534 (mRNA)
NP_001017534 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 11: 104.42 - 104.42 Mb

n/a

Pubmed search

[1]

n/a

Caspase-1 dominant-negative inhibitor pseudo-ICE, also known as COP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: COP1 caspase-1 dominant-negative inhibitor pseudo-ICE.

[edit] Further reading

Wang X, Narayanan M, Bruey JM, et al. (2006). "Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.". Biochim. Biophys. Acta 1762 (8): 742–54. doi:10.1016/j.bbadis.2006.06.015. PMID 16920334.
Wang X, Wang H, Figueroa BE, et al. (2006). "Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease.". J. Neurosci. 25 (50): 11645–54. doi:10.1523/JNEUROSCI.4181-05.2005. PMID 16354923.
Lamkanfi M, Denecker G, Kalai M, et al. (2005). "INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.". J. Biol. Chem. 279 (50): 51729–38. doi:10.1074/jbc.M407891200. PMID 15383541.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Razmara M, Srinivasula SM, Wang L, et al. (2002). "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.". J. Biol. Chem. 277 (16): 13952–8. doi:10.1074/jbc.M107811200. PMID 11821383.
Druilhe A, Srinivasula SM, Razmara M, et al. (2001). "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins.". Cell Death Differ. 8 (6): 649–57. doi:10.1038/sj/cdd/4400881. PMID 11536016.
Lee SH, Stehlik C, Reed JC (2001). "Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing.". J. Biol. Chem. 276 (37): 34495–500. doi:10.1074/jbc.M101415200. PMID 11432859.