Talk:Conjugated linoleic acid

From Wikipedia, the free encyclopedia

This article is within the scope of the following WikiProjects:
WikiProject Alternative medicine      (Rated Start-Class) Complementary and Alternative Medicine Portal This article is within the scope of the WikiProject on Alternative Medicine. Please visit the project page for more details, or ask questions on talk. Start This article has been rated as Start-class on the quality scale. WikiProject Chemicals (Rated Start-Class) Chemistry Portal Conjugated linoleic acid is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project. Start This article has been rated as Start-Class on the quality scale. Low This article has been rated as Low-importance on the importance scale. Article Grading: The following comments were left by the quality and importance raters: (edit · history · watch · refresh) CLA is of Mid importance; it gets a fair amount of coverage in the popular press, tho you probably wouldn't encounter it until a graduate-level class. In quality; it's between a Start and a B. Good - chembox with diagram, original identification, lots of well-formatted references. ToDo: Clean up large number of references that are not connected to text. I.e., put <ref> links from the body text to the reference text. Ideally, there would only be a couple of 'general references' and they'd be review articles. There is a lot more science that is mentioned in the refs than is actually summarized in the body text. Especially about the anti-cancer links. Some discussion of (putative) mechanisms by which CLA acts would be welcome The legal status of CLA as a trans fat needs stating, clarifying. Biosynthesis: CLAs are formed by bacteria in animal's rumens. Coverage of weight loss and muscle building is spotty, disconnected. Needs a section on commercial trade in CLA, which is a fairly large niche market. CLA is a hot topic in body-building circles; needs some discussion of how its been handle in the muscle press. David.Throop 20:07, 5 November 2007 (UTC) Molecular and Cellular Biology WikiProject (Rated Start-Class) MCB Portal This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The WikiProject's current monthly collaboration is focused on improving Restriction enzyme. Start This article has been rated as Start-Class on the assessment scale. Mid This article is on a subject of Mid-importance within molecular and cellular biology. Article Grading: The following comments were left by the quality and importance raters: (edit · history · refresh · how to use this template) CLA is of Mid importance; it gets a fair amount of coverage in the popular press, tho you probably wouldn't encounter it until a graduate-level class. In quality; it's between a Start and a B. Good - chembox with diagram, original identification, lots of well-formatted references. ToDo: Clean up large number of references that are not connected to text. I.e., put <ref> links from the body text to the reference text. Ideally, there would only be a couple of 'general references' and they'd be review articles. There is a lot more science that is mentioned in the refs than is actually summarized in the body text. Especially about the anti-cancer links. Some discussion of (putative) mechanisms by which CLA acts would be welcome The legal status of CLA as a trans fat needs stating, clarifying. Biosynthesis: CLAs are formed by bacteria in animal's rumens. Coverage of weight loss and muscle building is spotty, disconnected. Needs a section on commercial trade in CLA, which is a fairly large niche market. CLA is a hot topic in body-building circles; needs some discussion of how its been handle in the muscle press. David.Throop 20:07, 5 November 2007 (UTC) WikiProject Bodybuilding     (Rated Start-Class) This article is part of WikiProject Bodybuilding, an attempt to build a comprehensive and detailed guide to bodybuilding on Wikipedia. If you would like to participate, you can edit the article attached to this page, or visit the project page, where you can join the project and/or contribute to the discussion.
This article has an assessment summary page.

Contents 1 (No title) 2 Dab page 3 "Good trans fat" 4 Number of isomers 5 Contradiction 6 Mercola 7 Other Positive Health Claims 8 Dietary Sources 9 Contradiction 10 No geometric isomers 11 Number of CLAs 12 CAS Number 13 Opening sentence 14 Fifty percent higher?

[edit] (No title)

recent research have shown cla to be linked with several negative effects: oxidative stress, inflammation and most severe a reduced sensitivity to insulin (similar to diabetes). I am not very good at editing these pages, so i will just throw the info at the top together with the references, and let someone with more skills edit it into the text at a later time. dan.[1], [2] —Preceding unsigned comment added by 80.217.248.45 (talk) 07:00, 31 August 2007 (UTC)

[edit] Dab page

I'm not sure a disambiguation page is necessary unless the other CLAs are common enough. None of them seems remotely close to conjugated linoleic acid, thus there is little possibility of confusion.

Also, I just signed up so apparently I can't rename the article, but does anyone object to decapitalizing "conjugated linoleic acid"? It should not be capitalized despite the fact that is has an abbreviation composed of the capitalized initials (CLA).

I'm aware that a web search turns up many sites that do capitalize the term but take a look at some actual studies here. You'll note that the heading capitalizes the term but none of the study titles do. http://www.wisc.edu/fri/clarefs.htm

-VQuick

CLA stands for Collective Labour Agreement too. I'm not enough versied in Wiki editing to do the necessary manipulations, nor do i know if the wiki community agrees with Collective Labour Agreement too.

But not to forget Agencies, Bureaus, Schools like:

Copyright Licencing Agency Canadian Library Association Country Land & Business Association Computer Law Association California Library Association CLA Centre de linguistique appliquée de Besançon

and many more. I believe for my part, that a disambiguation is absolutely necessary… but i'm new here ;-)

[edit] "Good trans fat"

Isn't this the so-called "good trans fat"? Carolynparrishfan 17:34, 2 December 2005 (UTC)

[edit] Number of isomers

The first paragraph states that CLA is a family of eight isomers. The third paragraph says there are two isomers. We need consistency, or an explanation of the discrepancy.

--As stated in paragraph one: "Conjugated linoleic acid...refers to a family of many isomers of linoleic acid" I believe the third paragraph may be referring to CLA supplements.

[edit] Contradiction

Dietary CLA supplementation does not seem to have any adverse effects.

CLA should be taken with food to prevent side effects, including diarrhea, nausea, and stomachache.

These sentences clearly contradict each other, don't they? Aragorn2 18:07, 26 April 2006 (UTC)

Don't know where to put this - but this reader has had incidences when taking 1500 mg of CLA of feeling like his head is in the clouds, or buzzing or slight drunk. Very bizzare feeling from taking CLA and has caused me to stop taking it at points.

That would be original research and thus couldn't be part of the article. However, have you seen anything else pertaining to these side-effects online? Frankg 15:17, 28 March 2007 (UTC)

[edit] Mercola

Is it appropriate to cite Dr. Mercola as a source for this article? His reputation is in serious question. Selling health magnets on his main page?

Heh. No, I do not think he is a reputable source. A verifible and scientific study, yes. Rlove 20:55, 27 May 2006 (UTC)

Mercola isn't the real source of the info, so it's not so great to cite him. I have replaced him and one other citation with the original articles involved. --Slashme 21:22, 27 May 2006 (UTC)

---

[edit] Other Positive Health Claims

I've noticed that this article has a few references to positive health benefits of CLA that don't appear to be substantiated. The page referenced in the link [3] for instance claims that CLA "Lowers insulin resistance", whereas the journal articles I can find claim that it can worsen insulin resistance.

Additionally, I can't find an reference for the claim of "overall enhancement of the immune system".

Any thoughts on removing of that link and possibly removing those claims?

Ar-wiki 18:06, 19 February 2007 (UTC)

Um, Also, the page says something about "CLA improving breast and colon cancer." Partial Reference for this may be " "Conjugated linoleic acid (CLA) is a powerful anticancer agent in a number of tumor model systems;" which is said by this article: Conjugated linoleic acid induces apoptosisnext term of murine mammary tumor cells via Bcl-2 loss Lihui Oua, Clement Ipb, Barbara Lisafelda and Margot M. Ipa, Corresponding Author Contact Information, E-mail The Corresponding Author aDepartment of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA bDepartment of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA

Received 15 March 2007. Available online 26 March 2007.

149.4.108.117 13:35, 10 April 2007 (UTC)

This link I found mentions an article on the benefits of a CLA supplement along with a scientific study. http://healthandfitness.sympatico.msn.ca/Supplement+may+help+cut+fat/Home/ContentPosting_50Plus.aspx?isfa=1&newsitemid=e1cdd715-1c77-449f-a78a-37147d20e458&feedname=50_PLUS&show=True&number=3&showbyline=True&subtitle=&detect=&abc=abc

[edit] Dietary Sources

I'm thinking of removing the following line and ref as it really doesn't pertain to CLA.

"Some bakers and food producers are substituting palm oil for butter so that they can label their products as trans-fat free."

The preceding line about the CLA's nature as a transfat should be moved to the first paragraph of the article where that topic is discussed.

Any thoughts, complaints? Ar-wiki 23:44, 9 March 2007 (UTC)

[edit] Contradiction

Early in the article: "in the United States, trans linkages in a conjugated system are not counted as trans fat for the purposes of nutritional regulations and labeling." Later in the article: "Laws restricting trans fats do not distinguish between trans fats formed by partial hydrogenation and naturally occuring CLA." I'm pretty sure the first statement is correct and the second one is false, as far as the US goes. Any idea what's up with this? Frankg 00:25, 10 March 2007 (UTC)

The regulatory chemical definition of the FDA for trans fatty acids is "all unsaturated fatty acids that contain one or more isolated (i.e., non-conjugated) double bonds in a trans configuration."
So I think you're right. I was going to clean up that section anyway so I'll nip that one too. Ar-wiki 02:44, 10 March 2007 (UTC)

[edit] No geometric isomers

I corrected the definition at the beginning of the article. The double bonds have to be conjugated which is not the case in linoleic acid, so they are not geometric isomers. In fact, there are only 4 geometric isomers of linoleic acid (linoleic acid (Z,Z), linoelaidic acid (E,E), and the (E,Z) and (Z,E) variants, which don't have nonsystematic names as far as I know). Icek 20:55, 23 March 2007 (UTC)

[edit] Number of CLAs

The article currently says "at least 13 are reported". Well, there are 13 trans,trans-isomers if no double bond is allowed at the end of the chain (and one more if it is allowed, but maybe this is not occurring in natural CLAs due to biochemical reasons). There are 39 of them if you include trans,cis- and cis,trans-isomers. I'd like to see a more precise definition of what exactly is a CLA. Icek 01:19, 8 August 2007 (UTC)

My understanding is that should be understood as 'at least 13 have been reported in the literature." Many of the possible isomers have not been found in nature. David.Throop 19:31, 5 November 2007 (UTC)

[edit] CAS Number

Someone had left the cite for the CAS number as 2420-56-6; but that number comes up emptyhanded at CAS. David.Throop 19:31, 5 November 2007 (UTC)

[edit] Opening sentence

The opening sentence isn't a sentence!

"Conjugated linoleic acid (CLA) to a family of many isomers of linoleic acid (at least 13 are reported), which are found primarily in the meat and dairy products of ruminants." Unfree (talk) 09:53, 18 May 2008 (UTC)

[edit] Fifty percent higher?

This statement should be more explicit:

"[M]others consuming mostly organic milk and meat products have about 50 percent higher levels of rumenic acid in their breast milk."

Were they compared to women who ate similar amounts of milk and meat products, but ones which weren't organic? Unfree (talk) 11:30, 20 May 2008 (UTC)