Conrad-Limpach synthesis

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The Conrad-Limpach synthesis is the chemical reaction of anilines (1) with β-ketoesters (2) to form 4-hydroxyquinolines (4) via a Schiff base (3).[1][2][3]

The Conrad-Limpach synthesis

Several reviews have been published.[4][5]

[edit] References

  1. ^  Conrad, M.; Limpach, L. Ber. 1887, 20, 944.
  2. ^  Conrad, M.; Limpach, L. Ber. 1891, 24, 2990.
  3. ^  Reynolds, G. A.; Hauser, C. R. Org. Syn., Coll. Vol. 3, p.593 (1955); Vol. 29, p.70 (1949). (Article)
  4. ^  Manske, R. H. Chem. Rev. 1942, 30, 121. (Review)
  5. ^  Reitsema, R. H. Chem. Rev. 1948, 43, 47. (Review)

[edit] See also


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