User talk:Comcc
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Hi! Welcome to my talk page.
If you have any complaints about my contributions, please post them below. For a list of my contributions, please check out my wikipedia homepage.
If something that I have added is incorrect or inaccurate, please change it and make a note of it on this page. I'd like to know what I got wrong!
[edit] Welcome to the Wikipedia
Welcome, Comcc!
Here are some useful tips to ease you into the Wikipedia experience:
- First, take a look at the Wikipedia Tutorial, and perhaps dabble a bit in the test area.
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Also, here are some odds and ends that I find useful from time to time:
- Wikipedia:Five pillars
- Wikipedia:Brilliant prose
- Wikipedia:Be bold in updating pages
- Wikipedia:Bad jokes and other deleted nonsense
Feel free to ask me anything the links and talk pages don't answer. You can most easily reach me by posting on my talk page.
You can sign your name on any page by typing 4 tildes, likes this: Dr. Cash 05:01, 19 September 2007 (UTC).
Best of luck, and have fun! – ClockworkSoul 05:54, 23 October 2006 (UTC)
[edit] Oh - one more thing
Welcome to the MCB WikiProject. We can use all the help we can get! :) – ClockworkSoul 05:54, 23 October 2006 (UTC)
Wow that was fast. Thanks for the advice! ComCC 06:31, 23 October 2006 (UTC)
[edit] This month's winner is proteasome!
– ClockworkSoul 22:08, 1 November 2006 (UTC)
[edit] This month's winner is RNA interference!
– ClockworkSoul 14:32, 2 December 2006 (UTC)
[edit] This month's winner is Peripheral membrane protein!
– ComCC 06:20, 9 January 2007 (UTC)
[edit] This month's winner is Signal transduction!
– ComCC 07:25, 6 March 2007 (UTC)
[edit] This month's winner is RNA polymerase!
– ComCC 20:10, 15 April 2007 (UTC)
[edit] Your edit to Genetic code
I reworded and shortened your edit to Genetic code, hopefully I understood it correctly -- I think you were talking about it in the context of wobble base pairs? So I reduced it to a sentence and put it in that paragraph. I also made it speculative rather than a statement of fact. Could you provide a reference for this hypothesis? I'd like to make sure this isn't original research. Thanks! -Madeleine 01:19, 17 April 2007 (UTC)
- Thanks for helping! The new edit looks good, though the wording may be a little confusing. Also, my textbook states it as a fact rather than speculation. I will touch it up later tonight. As for the reference, can you help me do the citation? I don't know how to do citation linking...
- Lehninger Principles of Biochemistry, 4th edition, David L. Nelson & Michael M. Cox
- Its on pg. 1043. Thanks for the help! -ComCC 05:07, 17 April 2007 (UTC)
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- Sorry, this isn't a textbook I own, although I could take a half hour to look find a copy if needed. Can you see if there's an original paper referenced by the book for this particular claim? That'd be a much better reference than a textbook. Tell me if you can't find more -- I have someone I might ask about it, if you don't turn anything up. :-)
- Feel free to rewrite what I wrote for clarity purposes... Without any experimental evidence to back it up, I feel strongly that the statement should remain speculation (but interesting enough, perhaps, for wikipedia); even with some evidence, I think it'd take a lot to make it more than a plausible hypothesis. -Madeleine 05:13, 17 April 2007 (UTC)
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- I checked my textbook and it doesn't seem they reference the original paper. It's explained as part of the Wobble hypothesis, which was proposed by Francis Crick in 1966 (see PMID: 5969078), but I'm not sure if the point that we're discussing was part of his original hypothesis, discovered later, or a hypothesis of another researcher. I'll check some papers to see if there's anything about it... but I think you should check with the person you know, just in case. :) Thanks! -ComCC 08:09, 17 April 2007 (UTC)
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- Okay, my friend (who worked on tRNAs for her phd) said this speculation wasn't true and the opposite was true -- that wobble base-pairing actually makes translation slower. I've dug around for a paper that says this, and it's really hard to find anything either way. I ended up with this review:
- "Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes", Henri Grosjean and Walter Fiers. Gene, 18 (1982) 199-209.
- It's an old paper, but it compiles enough information that I'm satisfied that the speculation you added is not true (although I'm not sure I accept their hypothesis either). The paper is looking at codon usage bias in highly expressed E Coli genes -- codon usage bias seems to occur when there are selection pressures driving rapid and accurate translation. Several cases exist where there are tRNAs with "G" at the wobble position, which can pair with "A" or "C", and in a lot of these the watson-crick paired "C" is favored rather than the wobble-paired "A". However, it looks like the wobble codon possibility is favored in codons that are otherwise strong in interaction energy, "CG-rich" at the first two positions. The authors conclude that codon usage is optimized to keep the codon-anticodon hybridization energies roughly equal.
- But the whole thing looks pretty complicated. The current model for translation involves an error-checking process on top of the codon association. The free energy differences between a perfect match codon and mismatch are small enough that errors in translation would theoretically be fairly high -- 1 in 1000 -- but it's actually much lower than that. There's a step in the process which seems to check the structure for a good match. Since the free energy of codon-anticodon pairing isn't trivially related to translation accuracy, it also might not be trivially related to translation speed.
- So, I've removed statement from the Genetic code page. -- Madeleine 23:29, 23 April 2007 (UTC)
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[edit] Helicobacter pylori
Hi,
According to the spirillum article, spirillum refers to a genus of bacteria. Helicobacter pylori belongs to the Helicobacter genus. As to whether Helicobacter pylori is spiral or helical shaped, I made the edit based on the information in the article in spiral:
In mathematics, a spiral is a curve which emanates from a central point, getting progressively farther away as it revolves around the point.
...
A "spiral" and a "helix" are two terms that are easily confused, but represent different objects.
[edit] This month's winner is RNA!
– ComCC 00:43, 10 May 2007 (UTC)
[edit] This month's winner is Cell (biology)!
– ComCC 05:41, 9 September 2007 (UTC)
[edit] This month's winner is DNA Replication!
– ComCC 05:41, 9 September 2007 (UTC)
[edit] This month's winner is Cell cycle!
– ComCC 05:41, 9 September 2007 (UTC)
[edit] This month's winner is Extracellular matrix!
– ComCC 05:41, 9 September 2007 (UTC)
[edit] WikiProject Pharmacology Update
Here's a brief update in some of the recent developments of WikiProject Pharmacology!
- Aspirin has just completed its two week run as the first Collaboration of the Week! Many thanks to those editors that contributed; the article got a lot of good work accomplished, and in particular, much work was done in fixing up the history section. It's still not quite "done" yet (is a wikipedia article really ever done?), but after two weeks I think it's more important to push onwards with the development of the new collaboration of the week program. I will be fixing up Aspirin in the next few days and possibly nominating it for either GA or FA status.
- Muscle relaxant has been selected as the new Collaboration of the week until October 2, 2007! This article is currently rated as a "stub", so it's got quite a bit of work cut out for collaborators! Admittedly, featured status could be a long way off,... but still attainable! At the least, maybe we could at least get it up to meeting the Good article criteria? Please stop by the article and help improve it.
- Resveratrol, having recently achieved GA status on August 16, 2007, is now making a run for featured status. This is quite a fascinating compound. If you can, please stop by its discussion page and leave comments in support of it.
- Please remember that Wikipedia is not a forum for discussing or dispensing medical advice amongst users. Specifically, talk pages of articles should only be used to discuss improving the actual article in question. To help alleviate this situation, the template {{talkheader}} may be added to the top of talk pages, reminding users of the purpose of such pages. Additionally, unsigned comments and comments by anonymous users that are inappropriate may be removed from talk pages without being considered vandalism.
- There was an interesting article on ZDNet last week about Hewlett Packard licensing its patented microneedle technology used in common inkjet printers to be used in transdermal patches to deliver a time-controlled release of drugs to patients. This information could be added to articles such as route of administration or drug delivery.
You are receiving this message because you are listed as one of the participants of WikiProject Pharmacology.
Dr. Cash 05:01, 19 September 2007 (UTC)
[edit] WikiProject Pharmacology Update
Here are a few updates in the realm of WikiProject Pharmacology:
- The Pharmacology Collaboration of the Week has been changed to Collaboration of the Month, based on current participation levels. It is also more likely that articles collaborated on for one month are more likely to achieve featured quality than articles worked on for only a week or two.
- The current Collaboration of the Month for November is Receptor antagonist. Please take a look at that article and contribute to it if you get a chance. Ideally, the article should adhere to the featured article criteria.
- Therapies for multiple sclerosis is currently a featured article candidate. If you are familiar with the featured article criteria, please visit WP:FAC and review the article.
- Anabolic steroid is the wikiproject's newest Featured Article, having been promoted on October 8, 2007.
- Theobromine was delisted as a Good Article. The Peer review and GA reassessment discussions provide suggestions on improvement. Muscle relaxant was recently reviewed for Good Article status, but not promoted. Please see the full review full review here for details.
Dr. Cash 22:07, 31 October 2007 (UTC)
[edit] Can I interest you in ACTH stimulation test?
Based on your work on Hypothalamic-pituitary-adrenal axis I hope I can. ACTH stimulation test is a lonely page I stumbled across and tried to help, to little avail. But it looks like it may have enough value to make it worth saving – and maybe you can help. Consider having a look? 9Nak (talk) 08:48, 18 February 2008 (UTC)
