Talk:Compensation law of mortality

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Compensation law of mortality (late-life mortality convergence) states that the relative differences in death rates between different populations of the same biological species are decreasing with age, because the higher initial death rates in disadvantaged populations are compensated by lower pace of mortality increase with age.

Compensation law of mortality is a paradoxical empirical observation, and it represents a challenge for methods of data analysis based on proportionality assumption (proportinal hazard models). The compensation law of mortality also represents a great challenge for many theories of aging and mortality, which usually fail to explain this phenomenon. On the other hand, the compensation law follows directly from the reliability theory, when the compared systems have different initial levels of redundancy.

[edit] References

Gavrilov LA, Gavrilova NS. Reliability Theory of Aging and Longevity. In: Masoro E.J. & Austad S.N.. (eds.): Handbook of the Biology of Aging, Sixth Edition. Academic Press. San Diego, CA, USA, 2006, 3-42. ISBN 0120883872

Gavrilov LA, Gavrilova NS. Why We Fall Apart. Engineering's Reliability Theory Explains Human Aging. IEEE Spectrum, 2004, 41(9): 30-35.

Gavrilov LA, Gavrilova NS. The Reliability-Engineering Approach to the Problem of Biological Aging. Annals of the New York Academy of Sciences, 2004, 1019: 509-512. PMID 15247076

Gavrilov L.A., Gavrilova N.S. The quest for a general theory of aging and longevity. Science's SAGE KE (Science of Aging Knowledge Environment) for 16 July 2003; Vol. 2003, No. 28, 1-10. http://sageke.sciencemag.org , PMID 12867663

Gavrilov L.A., Gavrilova N.S. The reliability theory of aging and longevity. Journal of Theoretical Biology, 2001, 213(4): 527-545. PMID 11742523

Leonid A. Gavrilov & Natalia S. Gavrilova (1991), The Biology of Life Span: A Quantitative Approach. New York: Harwood Academic Publisher, ISBN 3718649837

Gavrilov, L.A., Gavrilova, N.S. Determination of species length of life. Proc. Acad. Sci. USSR [Doklady Akademii Nauk SSSR], 1979, 246(2): 465-469. English translation by Plenum Publ Corp: pp.905-908. PMID 111909

Gavrilov, L.A. A mathematical model of the aging of animals. Proc. Acad. Sci. USSR [Doklady Akademii Nauk SSSR], 1978, 238(2): 490-492. English translation by Plenum Publ Corp: pp.53-55. PMID 624242

Gavrilov, L.A., Gavrilova, N.S., Yaguzhinsky, L.S. The main regularities of animal aging and death viewed in terms of reliability theory. J. General Biology [Zhurnal Obschey Biologii], 1978, 39(5): 734-742. PMID 716614