Talk:Combretastatin
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Article Grading: The following comments were left by the quality and importance raters: (edit ยท refresh) Hi, I was wondering if anyone else has the same problem as me. There seems to be two compounds, COMBRESTATIN and COMBRETASTATIN, and much confusion about which structure goes with which name. According to ChemIDPlus (http://chem.sis.nlm.nih.gov/chemidplus/, which I would call pretty definitive) the compound COMBRETASTATIN (NAME: Combretastatin, RN: 82855-09-2) does not have the structure shown on the Wikipedia site. Indeed, the structure on the Wikipedia site is that of COMBRESTATIN, as sold by Cayman Chemical (http://www.caymanchem.com/app/template/Product.vm/catalog/10007412, a reliable supplier to my knowledge). I'm a chemist, so know a little about the subject, but perhaps someone else has any ideas, and can clear me up in the process. Thanks, Cmschultes 16:02, 18 October 2007 (UTC) |
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Hello I started this page. Combretastatin A-4 is the correct name and the structure is also correct. Combrestatin is incorrect or at the very least a variance of the correct nomenclature. Combretastatin A-4 is part of a larger family of natural products and synthetic analogs. When I search for that CAS number (117048-59-6) I also see Combretastatin A-4 results. Definitely a confusing mistake! Also, the ChemIDplus result for NAME: Combretastatin A-4 RN: 117048-59-6 shows the trans isomer which is technically correct, although the pharmacologically active CA-4 is the cis isomer. Silverweed 07:42, 13 November 2007 (UTC)
Edited the page to reflect a few recent updates, namely that CA-4 has reached its first phase III clinical trial (yay!) and is in numerous phase I and II trials. Check www.clinicaltrials.gov (search for combretastatin) for more info. Silverweed 07:53, 13 November 2007 (UTC)
Is Combretastatin supposed to be on the Statin page? If not (if it's not a statin), maybe that fact should be clarified in this article? Also, if Combretastatin is a statin (which I honestly don't know), then the Statin page should be updated with some information on the anti-cancer effects of Combretastatin. europrobe (talk) 17:29, 28 January 2008 (UTC)
Combretastatin is not a Statin, I'm not sure what the origin of the name is. Silverweed (talk) 11:02, 5 April 2008 (UTC)
