Talk:Combinatorial chemistry

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Somebody who really knows all about QSAR and similar bits of alphabet soup could add to this article. -- Marj Tiefert, Friday, May 17, 2002

[edit] improve it?

Marj, i´ve read the article and maybe we can improve it. There is a "term" coined in the scientific literature called Virtual HTS, e. g.: testing all the library members against its molecular target (a enzyme or a membran protein in most of the cases) in a computer, before the synthesis. Many things in the Combinatorial media are changing, specially the quantity of members in a comb. library, that is decreasing. What do you think about it? --Cedric.graebin 16:38, 17 August 2005 (UTC)

[edit] Truth or fiction? Do we care?

Here is the text of a POV edit I am removing from the article. Please comment. If majority opinion supports inclusion, then it will get put back into the text.

The first publication of a combinatorial library was by G. Pieczenik in 1987, with the publication of his foreign patent filings of the US patent 5,866,363 filed in 1985 with a disclosure document in 1983. http://www2.mrc-lmb.cam.ac.uk/archive/g_pieczenik.html. Pieczenik worked with Bruce Merrifield and Fred Sanger, among other Nobel laureates. A. Furka had a notarized copy of his idea of making mixed combinatorial libraries in 1982.http://www.chem.elte.hu/departments/szerves/szerves/Furka/ConcealedHTML.htm
  1. Remove: ~K 04:21, 5 September 2006 (UTC)
  2. Remove in part, reduce level of detail: From the tone, it sounds like the point of the Furka note is to cast aspersions on the originality of others cited, or at the outside extreme some conspiracy theory. Really need something more than just an interview with the person to consider including this. Notarized ideas aren't how science works. Regardless, need to keep claims and dates of originality on equal footing--everyone has ideas and preliminary/promising result leads long before an actual publication. The first sentence seems like reasonable material, but the level of detail about the patent is excessive. Regarding the earlier part of the paragraph, consider instead "The first publication of a combinatorial library was by G. Pieczenik in a patent disclosed in 1983[ref to the patent itself, or a secondary source about it]." The intricacies of what secondary contries got the patent and the timeline of the whole patent process aren't important. DMacks 00:12, 13 September 2006 (UTC)
  3. Remove - at least, this is the opinion that I think would be best for the article. If anything, that material can be added to something like History of Combinatorial Chemistry. --HappyCamper 22:45, 13 September 2006 (UTC)
  4. Remove Not helpful to the reader it seems to only involve some sort of legal establishment of facts for a patent dispute. If there is a patent dispute it could be mentioned as a dispute but only as a foot note. This article is about cominatorial chemistry not about who invented it. Yes the4 inventor could be mentioned but only if well established otherwise leave it out.--Nick Y. 01:39, 14 September 2006 (UTC)

Furka's 1982 statement is available at here. In Hungary some regard him as THE founder of combinatorial chemistry (e.g. Istvan Hargittai, who frequently writes on the Nobel prize, sometimes mentioning that Furka surely deserves one). It would be good to know what exactly his part was in inventing combinatorial chemistry. Kope (talk) 13:58, 5 January 2008 (UTC)