Complement component 3

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Complement component 3
PDB rendering based on 1c3d.
Available structures: 1c3d, 1ghq, 1w2s, 2a73, 2a74, 2b39, 2gox, 2hr0, 2i07, 2ice, 2icf
Identifiers
Symbol(s)	C3; ASP; CPAMD1
External IDs	OMIM: 120700 MGI: 88227 HomoloGene: 68031
Gene ontology Molecular Function: • endopeptidase inhibitor activity • receptor binding Cellular Component: • extracellular region Biological Process: • inflammatory response • complement activation, alternative pathway • complement activation, classical pathway • signal transduction • G-protein coupled receptor protein signaling pathway
Orthologs
	Human	Mouse
Entrez	718	12266
Ensembl	n/a	ENSMUSG00000024164
Uniprot	n/a	Q207D2
Refseq	NM_000064 (mRNA) NP_000055 (protein)	NM_009778 (mRNA) NP_033908 (protein)
Location	n/a	Chr 17: 56.89 - 56.91 Mb
Pubmed search	[1]	[2]

In immunology, soluble C3-convertase, also known as C4b2a, catalyzes the proteolytic cleavage of C3 into C3a and C3b as part of the classical complement system as well as the Mannan-binding lectin pathway. In the Alternative complement pathway, C3 is instead cleaved by iC3Bb, another form of C3-convertase.

Contents 1 See also 2 References 3 External links 4 Further reading

[edit] See also

• Complement system

[edit] References

[edit] External links

• Sahu A, Lambris J (2001). "Structure and biology of complement protein C3, a connecting link between innate and acquired immunity". Immunol Rev 180: 35–48. doi:10.1034/j.1600-065X.2001.1800103.x. PMID 11414361. 
• Fredslund F, Jenner L, Husted L, Nyborg J, Andersen G, Sottrup-Jensen L (2006). "The structure of bovine complement component 3 reveals the basis for thioester function". J Mol Biol 361 (1): 115–27. doi:10.1016/j.jmb.2006.06.009. PMID 16831446. 
• PDB 2B39, PDB 2A73
• domain structure; protein database
• MeSH Complement+C3

[edit] Further reading

v • d • e Proteins: complement system (C, L, A) Activators CLA: C3-convertase - C5-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin Enzymes C: C1Q/C1R/C1S - C4 (C4a) - C2 - CLA: C3 (C3a, C3b/iC3b) - C5 (C5a) - L: MASP1 - MASP2 - A: Complement factor B - Factor D Inhibitors CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H Complement receptors CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a)

v • d • e Acute phase proteins Amyloid SAP - SAA Other positive Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-macroglobulin - C-reactive protein - Ceruloplasmin - C3 - Fibrin - Haptoglobin - Haemopexin - Orosomucoid - Transferrin Negative Serum albumin