Columbamine oxidase

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In enzymology, a columbamine oxidase (EC 1.21.3.2) is an enzyme that catalyzes the chemical reaction

2 columbamine + O₂ 2 berberine + 2 H₂O

Thus, the two substrates of this enzyme are columbamine and O₂, whereas its two products are berberine and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on X-H and Y-H to form an X-Y bond with oxygen as acceptor. The systematic name of this enzyme class is columbamine:oxygen oxidoreductase (cyclizing). This enzyme is also called berberine synthase. This enzyme participates in alkaloid biosynthesis i. It employs one cofactor, iron.

[edit] References

• IUBMB entry for 1.21.3.2
• BRENDA references for 1.21.3.2 (Recommended.)
• PubMed references for 1.21.3.2
• PubMed Central references for 1.21.3.2
• Google Scholar references for 1.21.3.2
• Rueffer M and Zenk MH (1985). "Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis". Tetrahedron Lett. 26: 201–202. doi:10.1016/S0040-4039(00)61879-8. 

[edit] External links

The CAS registry number for this enzyme class is 95329-18-3.

• IUBMB entry for 1.21.3.2

• KEGG entry for 1.21.3.2

• BRENDA entry for 1.21.3.2

• NiceZyme view of 1.21.3.2

• EC2PDB: PDB structures for 1.21.3.2

• PRIAM entry for 1.21.3.2

• PUMA2 entry for 1.21.3.2

• IntEnz: Integrated Enzyme entry for 1.21.3.2

• MetaCyc entry for 1.21.3.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050455: columbamine oxidase

• AMIGO entry for GO code 0050455: columbamine oxidase