Columbamine O-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a columbamine O-methyltransferase (EC 2.1.1.118) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + columbamine S-adenosyl-L-homocysteine + palmatine

Thus, the two substrates of this enzyme are S-adenosyl methionine and columbamine, whereas its two products are S-adenosylhomocysteine and palmatine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:columbamine O-methyltransferase. This enzyme participates in alkaloid biosynthesis i.

[edit] References

• IUBMB entry for 2.1.1.118
• BRENDA references for 2.1.1.118 (Recommended.)
• PubMed references for 2.1.1.118
• PubMed Central references for 2.1.1.118
• Google Scholar references for 2.1.1.118
• Rueffer M, Amann M, Zenk MH (1986). "S-Adenosyl-L-methionine:columbamine O-methyltransferase, a compartmentalized enzyme in protoberberine biosynthesis". Plant Cell Reports 3: 182–185. 

[edit] External links

The CAS registry number for this enzyme class is 105843-76-3.

• IUBMB entry for 2.1.1.118

• KEGG entry for 2.1.1.118

• BRENDA entry for 2.1.1.118

• NiceZyme view of 2.1.1.118

• EC2PDB: PDB structures for 2.1.1.118

• PRIAM entry for 2.1.1.118

• PUMA2 entry for 2.1.1.118

• IntEnz: Integrated Enzyme entry for 2.1.1.118

• MetaCyc entry for 2.1.1.118

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0030778: columbamine O-methyltransferase

• AMIGO entry for GO code 0030778: columbamine O-methyltransferase