COL16A1

From Wikipedia, the free encyclopedia

Collagen, type XVI, alpha 1

Identifiers

COL16A1; 447AA; FP1572

External IDs

OMIM: 120326 MGI: 1095396 HomoloGene: 1397

Gene ontology
Molecular Function:	• structural molecule activity
Cellular Component:	• proteinaceous extracellular matrix • collagen type XVI • cytoplasm
Biological Process:	• phosphate transport • cell adhesion • female pregnancy

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001856 (mRNA)
NP_001847 (protein)

XM_992774 (mRNA)
XP_997868 (protein)

Location

Chr 1: 31.89 - 31.94 Mb

Chr 4: 129.55 - 129.6 Mb

Pubmed search

[1]

[2]

Collagen, type XVI, alpha 1, also known as COL16A1, is a human gene.^[1]

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.^[1]

[edit] References

^ ^a ^b Entrez Gene: COL16A1 collagen, type XVI, alpha 1.

[edit] Further reading

Yamaguchi N, Kimura S, McBride OW, et al. (1993). "Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments.". J. Biochem. 112 (6): 856–63. PMID 1284248.
Pan TC, Zhang RZ, Mattei MG, et al. (1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen.". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6565–9. PMID 1631157.
Sires UI, Dublet B, Aubert-Foucher E, et al. (1995). "Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase.". J. Biol. Chem. 270 (3): 1062–7. PMID 7836360.
Tillet E, Mann K, Nischt R, et al. (1995). "Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain.". Eur. J. Biochem. 228 (1): 160–8. PMID 7882999.
Grässel S, Timpl R, Tan EM, Chu ML (1997). "Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells.". Eur. J. Biochem. 242 (3): 576–84. PMID 9022684.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kassner A, Hansen U, Miosge N, et al. (2004). "Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils.". Matrix Biol. 22 (2): 131–43. PMID 12782140.
Kassner A, Tiedemann K, Notbohm H, et al. (2004). "Molecular structure and interaction of recombinant human type XVI collagen.". J. Mol. Biol. 339 (4): 835–53. doi:10.1016/j.jmb.2004.03.042. PMID 15165854.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Eble JA, Kassner A, Niland S, et al. (2006). "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains.". J. Biol. Chem. 281 (35): 25745–56. doi:10.1074/jbc.M509942200. PMID 16754661.