COG2

From Wikipedia, the free encyclopedia

Component of oligomeric golgi complex 2

Identifiers

COG2; LDLC

External IDs

OMIM: 606974 MGI: 1923582 HomoloGene: 7206

Gene ontology
Molecular Function:	• protein binding • protein transporter activity
Cellular Component:	• Golgi membrane • membrane • Golgi transport complex
Biological Process:	• protein amino acid glycosylation • intracellular protein transport • intra-Golgi vesicle-mediated transport • Golgi organization and biogenesis • oligosaccharide biosynthetic process • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007357 (mRNA)
NP_031383 (protein)

NM_029746 (mRNA)
NP_084022 (protein)

Location

Chr 1: 228.84 - 228.9 Mb

Chr 8: 127.41 - 127.44 Mb

Pubmed search

[1]

[2]

Component of oligomeric golgi complex 2, also known as COG2, is a human gene.^[1]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: COG2 component of oligomeric golgi complex 2.

[edit] Further reading

Salesiotis AN, Wang CK, Wang CD, et al. (1995). "Identification of novel genes from stomach cancer cell lines by differential display.". Cancer Lett. 91 (1): 47–54. PMID 7750094.
Podos SD, Reddy P, Ashkenas J, Krieger M (1994). "LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function.". J. Cell Biol. 127 (3): 679–91. PMID 7962052.
Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.". J. Biol. Chem. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.". J. Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMID 11980916.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex.". J. Biol. Chem. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Sohda M, Misumi Y, Yoshimura S, et al. (2007). "The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.". Traffic 8 (3): 270–84. doi:10.1111/j.1600-0854.2006.00530.x. PMID 17274799.