Coenzyme F420 hydrogenase

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In enzymology, a coenzyme F420 hydrogenase (EC 1.12.98.1) is an enzyme that catalyzes the chemical reaction

H₂ + coenzyme F₄20 $\rightleftharpoons$ reduced coenzyme F₄20

Thus, the two substrates of this enzyme are H₂ and coenzyme F420, whereas its product is reduced coenzyme F420.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with other, known, acceptors. The systematic name of this enzyme class is hydrogen:coenzyme F420 oxidoreductase. Other names in common use include 8-hydroxy-5-deazaflavin-reducing hydrogenase, F420-reducing hydrogenase, and coenzyme F420-dependent hydrogenase. This enzyme participates in folate biosynthesis. It has 3 cofactors: iron, Nickel, and Deazaflavin.

[edit] References

IUBMB entry for 1.12.98.1
BRENDA references for 1.12.98.1 (Recommended.)
PubMed references for 1.12.98.1
PubMed Central references for 1.12.98.1
Google Scholar references for 1.12.98.1
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Muth E, Morschel E, Klein A (1987). "Purification and characterization of an 8-hydroxy-5-deazaflavin-reducing hydrogenase from the archaebacterium Methanococcus voltae". Eur. J. Biochem. 169: 571–7. doi:10.1111/j.1432-1033.1987.tb13647.x. PMID 3121317.
Baron SF, Ferry JG (1989). "Purification and properties of the membrane-associated coenzyme F420-reducing hydrogenase from Methanobacterium formicicum". J. Bacteriol. 171: 3846–53. PMID 2738024.