Codeinone reductase (NADPH)

From Wikipedia, the free encyclopedia

In enzymology, a codeinone reductase (NADPH) (EC 1.1.1.247) is an enzyme that catalyzes the chemical reaction

codeine + NADP⁺ codeinone + NADPH + H⁺

Thus, the two substrates of this enzyme are codeine and NADP⁺, whereas its 3 products are codeinone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is codeine:NADP+ oxidoreductase. This enzyme participates in alkaloid biosynthesis i.

[edit] References

• IUBMB entry for 1.1.1.247
• BRENDA references for 1.1.1.247 (Recommended.)
• PubMed references for 1.1.1.247
• PubMed Central references for 1.1.1.247
• Google Scholar references for 1.1.1.247
• Lenz R and Zenk MH (1995). "Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum". Tetrahedron Lett. 36: 2449–2452. doi:10.1016/0040-4039(95)00278-K. 
• Lenz R, Zenk MH (1995). "Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants". Eur. J. Biochem. 233: 132–9. doi:10.1111/j.1432-1033.1995.132_1.x. PMID 7588736. 

[edit] External links

The CAS registry number for this enzyme class is 153302-41-1.

• IUBMB entry for 1.1.1.247

• KEGG entry for 1.1.1.247

• BRENDA entry for 1.1.1.247

• NiceZyme view of 1.1.1.247

• EC2PDB: PDB structures for 1.1.1.247

• PRIAM entry for 1.1.1.247

• PUMA2 entry for 1.1.1.247

• IntEnz: Integrated Enzyme entry for 1.1.1.247

• MetaCyc entry for 1.1.1.247

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047036: codeinone reductase (NADPH)

• AMIGO entry for GO code 0047036: codeinone reductase (NADPH)