Cobaltochelatase

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In enzymology, a cobaltochelatase (EC 6.6.1.2) is an enzyme that catalyzes the chemical reaction

ATP + hydrogenobyrinic acid a,c-diamide + Co₂+ + H₂O $\rightleftharpoons$ ADP + phosphate + cob(II)yrinic acid a,c-diamide + H⁺

The 4 substrates of this enzyme are ATP, hydrogenobyrinic acid a,c-diamide, Co2+, and H₂O, whereas its 4 products are ADP, phosphate, cob(II)yrinic acid a,c-diamide, and H⁺.

This enzyme belongs to the family of ligases, specifically those forming nitrogen-D-metal bonds in coordination complexes. The systematic name of this enzyme class is hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming). Other names in common use include hydrogenobyrinic acid a,c-diamide cobaltochelatase, CobNST, and CobNCobST. This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

IUBMB entry for 6.6.1.2
BRENDA references for 6.6.1.2 (Recommended.)
PubMed references for 6.6.1.2
PubMed Central references for 6.6.1.2
Google Scholar references for 6.6.1.2
Debussche L, Couder M, Thibaut D, Cameron B, Crouzet J, Blanche F (1992). "Assay, purification, and characterization of cobaltochelatase, a unique complex enzyme catalyzing cobalt insertion in hydrogenobyrinic acid a,c-diamide during coenzyme B12 biosynthesis in Pseudomonas denitrificans". J. Bacteriol. 174: 7445–51. PMID 1429466.
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19: 390–412. doi:10.1039/b108967f. PMID 12195810.