Cob(II)alamin reductase

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In enzymology, a cob(II)alamin reductase (EC 1.16.1.4) is an enzyme that catalyzes the chemical reaction

2 cob(I)alamin + NAD⁺ 2 cob(II)alamin + NADH + H⁺

Thus, the two substrates of this enzyme are cob(I)alamin and NAD⁺, whereas its 3 products are cob(II)alamin, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cob(I)alamin:NAD+ oxidoreductase. Other names in common use include vitamin B12r reductase, B12r reductase, and NADH2:cob(II)alamin oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, FAD.

[edit] References

• IUBMB entry for 1.16.1.4
• BRENDA references for 1.16.1.4 (Recommended.)
• PubMed references for 1.16.1.4
• PubMed Central references for 1.16.1.4
• Google Scholar references for 1.16.1.4
• Walker GA, Murphy S, Huennekens FM (1969). "Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems". Arch. Biochem. Biophys. 134: 95–102. doi:10.1016/0003-9861(69)90255-0. PMID 4390543. 

[edit] External links

The CAS registry number for this enzyme class is 37256-40-9.

• IUBMB entry for 1.16.1.4

• KEGG entry for 1.16.1.4

• BRENDA entry for 1.16.1.4

• NiceZyme view of 1.16.1.4

• EC2PDB: PDB structures for 1.16.1.4

• PRIAM entry for 1.16.1.4

• PUMA2 entry for 1.16.1.4

• IntEnz: Integrated Enzyme entry for 1.16.1.4

• MetaCyc entry for 1.16.1.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050453: cob(II)alamin reductase

• AMIGO entry for GO code 0050453: cob(II)alamin reductase