CoA-disulfide reductase

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In enzymology, a CoA-disulfide reductase (EC 1.8.1.14) is an enzyme that catalyzes the chemical reaction

2 CoA + NAD(P)+ $\rightleftharpoons$ CoA-disulfide + NAD(P)H + H⁺

The 3 substrates of this enzyme are CoA, NAD⁺, and NADP⁺, whereas its 4 products are CoA-disulfide, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is CoA:NAD(P)+ oxidoreductase. Other names in common use include CoA-disulfide reductase (NADH2), NADH2:CoA-disulfide oxidoreductase, CoA:NAD+ oxidoreductase, CoADR, and coenzyme A disulfide reductase.

[edit] References

IUBMB entry for 1.8.1.14
BRENDA references for 1.8.1.14 (Recommended.)
PubMed references for 1.8.1.14
PubMed Central references for 1.8.1.14
Google Scholar references for 1.8.1.14
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Crane EJ 3rd (2005). "Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii. Implications for this disulfide metabolism of anaerobic hyperthermophiles". FEBS. J. 272: 1189–200. doi:10.1111/j.1742-4658.2005.04555.x. PMID 15720393.