CNTNAP4

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Contactin associated protein-like 4
Identifiers
Symbol(s) CNTNAP4; CASPR4; KIAA1763
External IDs OMIM: 610518 MGI: 2183572 HomoloGene: 24912
Orthologs
Human Mouse
Entrez 85445 170571
Ensembl ENSG00000152910 ENSMUSG00000031772
Uniprot Q9C0A0 Q69ZB1
Refseq NM_033401 (mRNA)
NP_207837 (protein)		 NM_130457 (mRNA)
NP_569724 (protein)
Location Chr 16: 74.9 - 75.15 Mb Chr 8: 115.46 - 115.77 Mb
Pubmed search [1] [2]

Contactin associated protein-like 4, also known as CNTNAP4, is a human gene.[1]

This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.[1]

[edit] References

  1. ^ a b Entrez Gene: CNTNAP4 contactin associated protein-like 4.

[edit] Further reading

  • Kim JM, Lee KH, Jeon YJ, et al. (2007). "Identification of genes related to Parkinson's disease using expressed sequence tags.". DNA Res. 13 (6): 275-86. doi:10.1093/dnares/dsl016. PMID 17213182. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765. 
  • Spiegel I, Salomon D, Erne B, et al. (2002). "Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains.". Mol. Cell. Neurosci. 20 (2): 283-97. PMID 12093160. 
  • Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347-55. PMID 11214970. 
  • Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263-72. PMID 7757816. 
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