CNO (gene)

From Wikipedia, the free encyclopedia


Cappuccino homolog (mouse)
Identifiers
Symbol(s) CNO; FLJ11230
External IDs OMIM: 605695 MGI: 1929230 HomoloGene: 10155
Orthologs
Human Mouse
Entrez 55330 117197
Ensembl ENSG00000186222 ENSMUSG00000060708
Uniprot Q9NUP1 Q8VED2
Refseq NM_018366 (mRNA)
NP_060836 (protein)		 NM_133724 (mRNA)
NP_598485 (protein)
Location Chr 4: 6.77 - 6.77 Mb Chr 5: 37.04 - 37.04 Mb
Pubmed search [1] [2]

Cappuccino homolog (mouse), also known as CNO, is a human gene.[1]

This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky-Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking.[1]

[edit] References

  1. ^ a b Entrez Gene: CNO cappuccino homolog (mouse).

[edit] Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Starcevic M, Dell'Angelica EC (2004). "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).". J. Biol. Chem. 279 (27): 28393-401. doi:10.1074/jbc.M402513200. PMID 15102850. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Li W, Zhang Q, Oiso N, et al. (2003). "Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1).". Nat. Genet. 35 (1): 84-9. doi:10.1038/ng1229. PMID 12923531. 
  • Ciciotte SL, Gwynn B, Moriyama K, et al. (2003). "Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1).". Blood 101 (11): 4402-7. doi:10.1182/blood-2003-01-0020. PMID 12576321. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Moriyama K, Bonifacino JS (2003). "Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles.". Traffic 3 (9): 666-77. PMID 12191018. 
  • Gwynn B, Ciciotte SL, Hunter SJ, et al. (2001). "Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism.". Blood 96 (13): 4227-35. PMID 11110696. 
 This article on a gene on chromosome 4 is a stub. You can help Wikipedia by expanding it.