CNOT7

From Wikipedia, the free encyclopedia

CCR4-NOT transcription complex, subunit 7

PDB rendering based on 2d5r.

Available structures: 2d5r

Identifiers

Symbol(s)

CNOT7; CAF1; hCAF-1

External IDs

OMIM: 604913 MGI: 1298230 HomoloGene: 49011

Gene ontology
Molecular Function:	• transcription factor activity • signal transducer activity • protein binding • transcription activator activity
Cellular Component:	• nucleus • CCR4-NOT complex
Biological Process:	• carbohydrate metabolic process • transcription • regulation of transcription, DNA-dependent • signal transduction • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_013354 (mRNA)
NP_037486 (protein)

NM_011135 (mRNA)
NP_035265 (protein)

Location

Chr 8: 17.13 - 17.15 Mb

Chr 8: 41.99 - 42.01 Mb

Pubmed search

[1]

[2]

CCR4-NOT transcription complex, subunit 7, also known as CNOT7, is a human gene.^[1]

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: CNOT7 CCR4-NOT transcription complex, subunit 7.

[edit] Further reading

Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes.". Nature 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749.
Draper MP, Salvadore C, Denis CL (1995). "Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex.". Mol. Cell. Biol. 15 (7): 3487–95. PMID 7791755.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Rouault JP, Prévôt D, Berthet C, et al. (1998). "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex.". J. Biol. Chem. 273 (35): 22563–9. PMID 9712883.
Bogdan JA, Adams-Burton C, Pedicord DL, et al. (1999). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.". Biochem. J. 336 ( Pt 2): 471–81. PMID 9820826.
Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, et al. (2000). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.". Oncogene 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.
Albert TK, Lemaire M, van Berkum NL, et al. (2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.". Nucleic Acids Res. 28 (3): 809–17. PMID 10637334.
Prévôt D, Morel AP, Voeltzel T, et al. (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.". Jpn. J. Cancer Res. 92 (6): 592–6. PMID 11429045.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Flanagan J, Healey S, Young J, et al. (2003). "Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer.". Int. J. Cancer 106 (4): 505–9. doi:10.1002/ijc.11264. PMID 12845644.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Robin-Lespinasse Y, Sentis S, Kolytcheff C, et al. (2007). "hCAF1, a new regulator of PRMT1-dependent arginine methylation.". J. Cell. Sci. 120 (Pt 4): 638–47. doi:10.1242/jcs.03357. PMID 17264152.