CNOT6

From Wikipedia, the free encyclopedia

CCR4-NOT transcription complex, subunit 6

Identifiers

CNOT6; CCR4; KIAA1194

External IDs

OMIM: 608951 MGI: 2144529 HomoloGene: 69187

Gene ontology
Molecular Function:	• magnesium ion binding • RNA binding • exonuclease activity • protein binding • hydrolase activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015455 (mRNA)
NP_056270 (protein)

XM_910506 (mRNA)
XP_915599 (protein)

Location

Chr 5: 179.85 - 179.94 Mb

Chr 11: 49.52 - 49.56 Mb

Pubmed search

[1]

[2]

CCR4-NOT transcription complex, subunit 6, also known as CNOT6, is a human gene.^[1]

The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates.^[1]

[edit] References

^ ^a ^b Entrez Gene: CNOT6 CCR4-NOT transcription complex, subunit 6.

[edit] Further reading

Okubo K, Itoh K, Fukushima A, et al. (1996). "Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles.". Genomics 30 (2): 178-86. doi:10.1006/geno.1995.9887. PMID 8586417.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337-45. PMID 10574462.
Albert TK, Lemaire M, van Berkum NL, et al. (2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.". Nucleic Acids Res. 28 (3): 809-17. PMID 10637334.
Dupressoir A, Morel AP, Barbot W, et al. (2003). "Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding.". BMC Genomics 2 (1): 9. PMID 11747467.
Chen J, Chiang YC, Denis CL (2002). "CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase.". EMBO J. 21 (6): 1414-26. doi:10.1093/emboj/21.6.1414. PMID 11889047.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Chang TC, Yamashita A, Chen CY, et al. (2004). "UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.". Genes Dev. 18 (16): 2010-23. doi:10.1101/gad.1219104. PMID 15314026.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942-54. doi:10.1007/s00335-005-0075-2. PMID 16341674.