CNOT2

From Wikipedia, the free encyclopedia

CCR4-NOT transcription complex, subunit 2

Identifiers

CNOT2; CDC36; HSPC131; NOT2; NOT2H

External IDs

OMIM: 604909 MGI: 1919318 HomoloGene: 40953

Gene ontology
Molecular Function:	• RNA polymerase II transcription mediator activity • transcription regulator activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • regulation of global transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014515 (mRNA)
NP_055330 (protein)

NM_001037846 (mRNA)
NP_001032935 (protein)

Location

Chr 12: 68.92 - 69.03 Mb

Chr 10: 115.89 - 115.99 Mb

Pubmed search

[1]

[2]

CCR4-NOT transcription complex, subunit 2, also known as CNOT2, is a human gene.^[1]

[edit] References

^ Entrez Gene: CNOT2 CCR4-NOT transcription complex, subunit 2.

[edit] Further reading

Albert TK, Lemaire M, van Berkum NL, et al. (2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.". Nucleic Acids Res. 28 (3): 809–17. PMID 10637334.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zwartjes CG, Jayne S, van den Berg DL, Timmers HT (2004). "Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex.". J. Biol. Chem. 279 (12): 10848–54. doi:10.1074/jbc.M311747200. PMID 14707134.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Shi J, Nelson MA (2005). "The cyclin-dependent kinase 11 interacts with NOT2.". Biochem. Biophys. Res. Commun. 334 (4): 1310–6. doi:10.1016/j.bbrc.2005.07.026. PMID 16039607.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Jayne S, Zwartjes CG, van Schaik FM, Timmers HT (2006). "Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex.". Biochem. J. 398 (3): 461–7. doi:10.1042/BJ20060406. PMID 16712523.