CNKSR1

From Wikipedia, the free encyclopedia

Connector enhancer of kinase suppressor of Ras 1

PDB rendering based on 1wwv.

Available structures: 1wwv

Identifiers

Symbol(s)

CNKSR1; CNK; KSR; CNK1

External IDs

OMIM: 603272 MGI: 2670958 HomoloGene: 4604

Gene ontology
Molecular Function:	• protein binding, bridging
Cellular Component:	• plasma membrane • intercellular junction • cell cortex
Biological Process:	• transmembrane receptor protein tyrosine kinase signaling pathway • Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006314 (mRNA)
NP_006305 (protein)

XM_110525 (mRNA)
XP_110525 (protein)

Location

Chr 1: 26.38 - 26.39 Mb

n/a

Pubmed search

[1]

[2]

Connector enhancer of kinase suppressor of Ras 1, also known as CNKSR1, is a human gene.^[1]

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Therrien M, Wong AM, Rubin GM (1998). "CNK, a RAF-binding multidomain protein required for RAS signaling.". Cell 95 (3): 343-53. PMID 9814705.
Therrien M, Wong AM, Kwan E, Rubin GM (1999). "Functional analysis of CNK in RAS signaling.". Proc. Natl. Acad. Sci. U.S.A. 96 (23): 13259-63. PMID 10557308.
Hartsough MT, Morrison DK, Salerno M, et al. (2002). "Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway.". J. Biol. Chem. 277 (35): 32389-99. doi:10.1074/jbc.M203115200. PMID 12105213.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Matheny SA, Chen C, Kortum RL, et al. (2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.". Nature 427 (6971): 256-60. doi:10.1038/nature02237. PMID 14724641.
Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways.". Mol. Cell. Biol. 24 (4): 1736-46. PMID 14749388.
Rabizadeh S, Xavier RJ, Ishiguro K, et al. (2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.". J. Biol. Chem. 279 (28): 29247-54. doi:10.1074/jbc.M401699200. PMID 15075335.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Jaffe AB, Hall A, Schmidt A (2005). "Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho.". Curr. Biol. 15 (5): 405-12. doi:10.1016/j.cub.2004.12.082. PMID 15753034.
Ziogas A, Moelling K, Radziwill G (2005). "CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation.". J. Biol. Chem. 280 (25): 24205-11. doi:10.1074/jbc.M413327200. PMID 15845549.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Fritz RD, Radziwill G (2006). "The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor.". Biochem. Biophys. Res. Commun. 338 (4): 1906-12. doi:10.1016/j.bbrc.2005.10.168. PMID 16289034.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.